Abteilung für klinische Studien der Neurologischen Klinik (September 2024)

Enroll-HD: A prospective Registry Study in a Global Huntington’s Disease Cohort. Observational, prospective, multinational, multi-centre study without experimental treatment.

Eudra-CT: 2016-001378-13 / StimTox: A randomized, sham-controlled trial of pallidal neurostimulation versus botulinum toxine treatment for cervical dystonia.

EudraCT: 2018-001639-35 / PATTERN: Prospective, randomized, double-blind, placebo-controlled, multicenter study to investigate the efficacy and safety of NT 201 in the treatment of lower limb spasticity caused by stroke or traumatic brain injury in adult subjects, followed by an open label extension with or without combined upper limb treatment. PATTERN (Merz). Protocol Code: M602011014. Phase 3. 

Eudra-CT: 2021-003879-34 / ROCK-PD: Phase IIa. Multi-center, prospective,interventional, randomized, double-blind, placebo-controlled, parallel-group, non-inferiority. Safety, Tolerability and Symptomatic Efficacy of the ROCK-Inhibitor Fasudil in Patients with Parkinson’s Disease.

Eudra-CT: 2021-004849-20 / 283PD201 LUMA Study: A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of BIIB122 in Participants with Parkinson’s Disease.

VERCISE DBS PD: Registry of Deep Brain Stimulation with the VERCISE™ System (Vercise DBS Registry). A prospective, on-label, multi-center, international Registry. 

VERCISE Dystonia: Registry of Deep Brain Stimulation with the VERCISE™ System for treatment of Dystonia: Vercise DBS Dystonia Registry. A prospective, on-label, multi-center, international Registry. 

DysTract: Deutsches Netzwerk zur translationalen Erforschung und Behandlung dystoner Erkrankungen. DysTract - Eine multizentrische Registerstudie. 

STEEROPT: Can subthalamic stimulation using directional electrodes improve postoperative management in Parkinson’s disease? A post-market study.

The Essential Tremor Registry: Study Reference Number: A4080. Boston Scientific Registry of Deep Brain Stimulations for treatment of Essential Tremor (ET). 

EFRONT: Epidemiological Study in Frontotemporal Dementia. An international, multicentre, epidemiological observational Study. 

DIPS: Bildgebungsunterstützte Programmierung der Tiefen Hirnstimulation im internen Globus pallidus bei Dystonie-Patienten

ReTune: Zentrale Datenbank des Projektes INF des Collaborative Research Centre (CRC/TRR295) zur Erfassung klinischer Kerndaten 

ODEA-TIA: Optimal Detection of Atrial fibrillation in Transient Ischemic Attack 

FIND-AF 2 study: Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism

CAEHR Project: Herzkreislauferkrankungen – Verbesserung der Gesundheitsversorgung durch sektorenübergreifende Integration von Routinedaten

ESCAPE-MeVO: A Multicenter, Prospective, Randomized, Parallel Group, Open-label Design to Determine the Efficacy and Safety of Endovascular Thrombectomy for ischemic stroke patients with symptomatic Acute Medium Vessel Intracranial Occlusions

REVERXaL: A multinational observational longitudinal study to describe the patient characteristics, health care interventions, and health outcomes of patients with major bleedings in the presence of Factor Xa inhibitor treatment 

EU-CT: 2022-501176-26-00. LIBREXIA: A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor Xia Inhibitor, for Stroke Prevention after an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack.

ToSEE: Treatment of Established Status Epilepticus in the Elderly – a prospective, randomized, double-blind comparative effectiveness trial 

SMArtCARE: Longitudinal Data Collection from Patients with Spinal Muscular Atrophy 

Defizite und Verbesserungspotential in der psychosozialen und palliative Versorgung von ALS-Patient*innen in Deutschland 

ARGX-117-2202 IMMERSION: Multicenter Prospective Longitudinal Study of Clinical Outcomes, Disease Course, Health-Related Quality of Life, and Health Care Resource Utilization in Adult Patients With Multifocal Motor Neuropathy

Eudra-CT: 2019-001423-12 / GENERATE-BOOST: Multizentrische, randomisierte, kontrollierte und doppelblinde Studie zur Überprüfung der Wirksamkeit und Sicherheit von Bortezomib bei Patienten mit schwerer autoimmuner Enzephalitis.

MoOzart: Protocol Number: ML42393. Impact of Ocrelizumab on Patient Reported Fatigue and Quality of Life in RMS Patients treated for the first time with Ocrelizumab (Moozart).

ARGX-113-NIS-2209: Non-interventional, prospective study to understand real world use of efgartigimod in the treatment of generalised myasthenia gravis in Germany