Publikationen Pädiatrische Onkologie, Hämatologie und Stammzelltransplantation
2023
Akahoshi Y, Spyrou N, Hogan WJ, Ayuk F, DeFilipp Z, Weber D, Choe HK, Hexner EO, Rösler W, Etra AM, Sandhu K, Yanik GA, Chanswangphuwana C, Kitko CL, Reshef R, Kraus S, Wölfl M, Eder M, Bertrand H, Qayed M, Merli P, Grupp SA, Aguayo-Hiraldo P, Schechter T, Ullrich E, Baez J, Beheshti R, Gleich S, Kowalyk S, Morales G, Young R, Kwon D, Nakamura R, Levine JE, Ferrara JLM, Chen YB (2023)
Incidence, clinical presentation, risk factors, outcomes, and biomarkers in de novo late acute GVHD.
Blood Adv. 2023 Aug 22;7(16):4479-4491.
Zur Publikation
Al-Samkari H, Grace RF, Glenthøj A, Andres O, Barcellini W, Galactéros F, Kuo KHM, Layton DM, Morado Arias M, Viprakasit V, Dong Y, Tai F, Hawkins P, Gheuens S, Morales-Arias J, Gilroy KS, Porter JB, van Beers EJ (2023)
Early-onset reduced bone mineral density in patients with pyruvate kinase deficiency.
Am J Hematol. 2023 Mar;98(3):E57-E60.
Zur Publikation
Ballmaier M*, Germeshausen M*, Schulze H, Andres O (2023)
THROMKIDplus Patient Registry and Biomaterial Banking for Children with Inherited Platelet Disorders.
Hämostaseologie. 2023 Nov 2. Online ahead of print.
Zur Publikation
Bettkober M, Wiegering VA, Härtel C, Jürgen K, Genzel D, Wirth C, Monoranu C, Nothhaft M, Woelfl M, Schlegel PG (2023)
Case report: Unclear Inflammatory Reaction in an Eleven-Year-Old-Girl - Meningioma].
Klin Padiatr. 2023 Nov;235(6):373-375.
Zur Publikation
Del Bufalo F., De Angelis B., Caruana I., Del Baldo G., De Ioris M.A., Serra A., Mastronuzzi A., Cefalo M.G., Pagliara D., Amicucci M., Li Pira G., Leone G., Bertaina V., Sinibaldi M., Di Cecca S., Marica G., Zeinab A., Iaffaldano L., Gunetti M., Iacovelli S., Bugianesi R., Macchia S., Algeri M., Merli P., Galaverna F., Abbas R., Garganese M.C., Villani M.F., Colafati G.S., Bonetti F., Rabusin M., Perruccio K., Folsi V., Quintarelli C., Locatelli F (2023)
Third generation GD2-CART01 for relapsed/refractory high-risk neuroblastoma.
New England Journal of Medicine, 2023; 388(14): 1284-1295.
Zur Publikation
Di Matteo S., Munari E., Fiore P.F., Santopolo S., Sampaoli C., Pelosi A., Chouaib S., Tumino N., Vacca P., Mariotti F., Ebert S., Machwirth M., Haas D., Pezzullo M., Pietra G., Grottoli M., Buart S., Mortier E., Maggi E., Moretta L., Caruana I.*, Azzarone B.* (2023)
Role of different forms of IL-15 in human melanoma progression.
Frontiers in Immunology, 2023; 14:1183668.
Zur Publikation
Elitzur S, Vora A, Burkhardt B, Inaba H, Attarbaschi A, Baruchel A, Escherich G, Gibson B, Liu HC, Loh M, Moorman AV, Möricke A, Pieters R, Uyttebroeck A, Baird S, Bartram J, Barzilai-Birenboim S, Batra S, Ben-Harosh M, Bertrand Y, Buitenkamp T, Caldwell K, Drut R, Geerlinks AV, Gilad G, Grainger J, Haouy S, Heaney N, Huang M, Ingham D, Krenova Z, Kuhlen M, Lehrnbecher T, Manabe A, Niggli F, Paris C, Revel-Vilk S, Rohrlich P, Sinno MG, Szczepanski T, Tamesberger M, Warrier R, Wolfl M, Nirel R, Izraeli S, Borkhardt A, Schmiegelow K. (2023)
EBV-driven lymphoid neoplasms associated with pediatric ALL maintenance therapy.
Blood. 2023 Feb 16;141(7):743-755.
Zur Publikation
Giansanti M., Theinert T., Boeing S.K., Haas D., Schlegel P.G., Vacca P., Nazio F.* and Caruana I.* (2023)
Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies.
Molecular Cancer, 2023; 22(1):201.
Zur Publikation
Hartlapp I, Hartrampf PE, Serfling SE, Wild V, Weich A, Rasche L, Roth S, Rosenwald A, Mihatsch PW, Hendricks A, Wiegering A, Wiegering V, Hänscheid H, Schirbel A, Werner RA, Buck AK, Wester HJ, Einsele H, Kunzmann V, Lapa C, Kortüm KM. (2023)
CXCR4-Directed Imaging and Endoradiotherapy in Desmoplastic Small Round Cell Tumors.
J. Nucl Med. 2023 Sep;64(9):1424-1430.
Zur Publikation
Marabitti V., Caruana I.*, Nazio F.* (2023)
Should I stay or should I go? Spatio-temporal control of cellular anchorage by hematopoietic factors orchestrates tumor metastatic cascade.
Molecular Cancer, 2023; 22(1):149.
Zur Publikation
Marquardt V, Theruvath J, Pauck D, Picard D, Qin N, Blümel L, Maue M, Bartl J, Ahmadov U, Langini M, Meyer FD, Cole A, Cruz-Cruz J, Graef CM, Wölfl M, Milde T, Witt O, Erdreich-Epstein A, Leprivier G, Kahlert U, Stefanski A, Stühler K, Keir ST, Bigner DD, Hauer J, Beez T, Knobbe-Thomsen CB, Fischer U, Felsberg J, Hansen FK, Vibhakar R, Venkatraman S, Cheshier SH, Reifenberger G, Borkhardt A, Kurz T, Remke M, Mitra S. (2023) Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation.
J Immunother Cancer. 2023 Jan;11(1):e005871.
Zur Publikation
Nava Lauson C.B., Tiberti S., Corsetto P., Conte F., Punit T., Machwirth M., Ebert S., Loffreda A., Scheller L., Sheta D., Peters T., Raman A.T., Greco F., Rizzo A., Beilhack A., Signori G., Tumino N., Vacca P., McDonnell L., Raimondi A., Greenberg P.D., Huppa J.B., Cardaci S., Caruana I., Rodighiero S., Nezi L., Manzo T. (2023)
Linoleic acid potentiates CD8+ T cell metabolic fitness and anti-tumor immunity.
Cell Metabolism, 2023; 35(4): 633-650.e9.
Zur Publikation
Papan C, Reifenrath K, Last K, Attarbaschi A, Graf N, Groll AH, Hübner J, Laws HJ, Lehrnbecher T, Liese JG, Martin L, Tenenbaum T, Vieth S, von Both U, Wagenpfeil G, Weichert S, Hufnagel M, Simon A; AB-PPS PedOnc Study Group (2023) Antimicrobial use in pediatric oncology and hematology in Germany and Austria, 2020/2021: a cross-sectional, multi-center point-prevalence study with a multi-step qualitative adjudication process.
Lancet Reg Health Eur. 2023 Mar 1;28:100599.
Zur Publikation
Pagotto S., Simeone P., Brocco D., Catitti G., De Bellis D., Vespa S., Di Pietro N., Marinelli L., Di Stefano A., Veschi S., De Lellis L., Verginelli F., Kaitsas F., Iezzi M., Pandolfi A., Visone R., Tinari N., Caruana I., Di Ianni M., Cama A., Lanuti P., Florio R (2023)
CAR-T Derived Extracellular Aesicles: a Promising Development of CAR-T Anti-Tumor Therapy.
Cancers, 2023; 15(4):1052.
Zur Publikation
Riedmeier M, Thompson L, Molins CAF, Decarolis B, Härtel C, Schlegel P-G, Fassnacht M, Wiegering V (2023)
Prognostic value of the Weiss and Wieneke(AFIP) scoring systems in pediatric ACC.
Endocr Relat Cancer 2023;ERC-22-0259.
Zur Publikation
Ruopp M., Reiländer S., Haas D., Caruana I., Kronenberg D., Schmehl W., Stange R., Meinel L. (2023)
Transdermal carbon monoxide delivery.
Journal of Controlled Released, 2023; 357: 299-308.
Zur Publikation
Ruopp M., Zhu S., Worschech R., Haas D., Maschauer S., Prante O., Meinel L., Lühmann T. (2023)
Bioconjugation of a Fibroblast Activation Protein Targeted Interleukin-4.
ACS Biomater Sci Eng.; 2023; 9;9(10):5580-5588.
Zur Publikation
Spyrou N, Akahoshi Y, Ayuk F, Holler E, Choe H, Etra A, Hogan WJ, Rösler W, Hexner E, DeFilipp Z, Reshef R, Chanswangphuwana C, Qayed M, Kraus S, Eder M, Javorniczky NR, Grupp SA, Kitko CL, Merli P, Aguayo-Hiraldo P, Wölfl M, Baez J, Beheshti R, Eng G, Gleich S, Katsivelos N, Khan A, Kowalyk S, Morales G, Young R, Nakamura R, Chen YB, Levine JE, Ferrara JLM. (2023)
The utility of biomarkers in acute GVHD prognostication. Blood Adv. 2023 Sep 12;7(17):5152-5155.
Zur Publikation
Svec P, Elfeky R, Galimard JE, Higham CS, Dalissier A, Quigg TC, Bueno Sanchez D, Han Lum S, Faraci M, Cole T, Pichler H, Benítez-Carabante MI, Horakova J, Gonzalez-Vicent M, Yanir A, Fagioli F, Wölfl M, von der Weid N, Protheroe R, Krivan G, Speckmann C, James B, Avcin SL, Bertrand Y, Verna M, Riha P, Patrick K, Cesaro S, Kalwak K, Bierings M, Büchner J, Mellgren K, Prohászka Z, Neven B, Lankester A, Corbacioglu S. (2023)
Use of eculizumab in children with allogeneic haematopoietic stem cell transplantation associated thrombotic microangiopathy - a multicentre retrospective PDWP and IEWP EBMT study.
Bone Marrow Transplant. 2023 Feb;58(2):129-141.
Zur Publikation
Uttinger KL, Reibetanz J, Diers J, Baum P, Pietryga S, Hendricks A, Schütze L, Baumann N, Wiegering V, Lock J, Dischinger U, Seyfried F, Fassnacht M, Germer CT, Wiegering A. (2023)
Volume-outcome relationship in adrenal surgery from 2009-2017 in Germany-a retrospective study.
Eur J Endocrinol. 2023 Jan 10;188(1):lvac013.
Zur Publikation
Weber D, Weber M, Meedt E, Ghimire S, Wolff D, Edinger M, Poeck H, Hiergeist A, Gessner A, Ayuk F, Roesler W, Wölfl M, Kraus S, Zeiser R, Bertrand H, Bader P, Ullrich E, Eder M, Gleich S, Young R, Herr W, Levine JE, Ferrara JLM, Holler E (2023)
Reg3α concentrations at day of allogeneic stem cell transplantation predict outcome and correlate with early antibiotic use.
Blood Adv. 2023 Apr 11;7(7):1326-1335.
Zur Publikation
2022
Al-Samkari H, Galactéros F, Glenthøj A, Rothman JA, Andres O, Grace RF, Morado-Arias M, Layton DM, Onodera K, Verhovsek M, Barcellini W, Chonat S, Judge MP, Zagadailov E, Xu R, Hawkins P, Beynon V, Gheuens S, van Beers EJ (2022)
Mitapivat versus Placebo for Pyruvate Kinase Deficiency.
N Engl J Med. 2022 Apr 14;386(15):1432-1442.
doi: 10.1056/NEJMoa2116634.
Augustin AM, Kertels O, Wiegering V, Thurner A, Kickuth R (2022)
Percutaneous implantation of peripherally inserted totally implantable venous access systems in the forearm in adolescent patients.
Pediatr Radiol. 2022. doi: 10.1007/s00247-022-05321
Bethge W, Eyrich M, Mielke S, Meisel R, Niederwieser D, Schlegel PG, Schulz A, Greil J, Bunjes D, Bader P, Brecht A, Kuball J, Schumm M, Vucinic V, Wiesneth M, Bonig H, Westinga K, Biedermann S, Holtkamp S, Karitzky S, Malchow M, Siewert C, Handgretinger R, Lang P (2022)
Results of a phase I/II trial of TCRab and CD19 depleted haploidentical HSCT for adult and pediatric patients.
Bone Marrow Transplant 2022;57(3):423-430.
Buechner J, Caruana I, Künkele A, Rives S, Vettenranta K, Bader P, Peters C, Baruchel A, Calkoen F (2022)
Chimeric Antigen Receptor T-Cell Therapy in Paediatric B-Cell Precursor Acute Lymphoblastic Leukaemia: Curative Treatment Option or Bridge to Transplant?
Front Pediatr. 2022;9:784024.
Etra AM, Gergoudis SC, Morales G, Spyrou N, Shah J, Kowalyk S, Ayuk FA, Baez J, Chanswangphuwana C, Chen YB, Choe HK, DeFilipp Z, Gandhi I, Hexner E, Hogan WJ, Holler E, Kapoor U, Kitko CL, Kraus S, Lin JY, Al Malki MM, Merli P, Pawarode A, Pulsipher MA, Qayed M, Reshef R, Roesler W, Schechter T, Van Hyfte G, Weber D, Wölfl M, Young R, Özbek U, Ferrara JL, Levine JE (2022)
Assessment of systemic and gastrointestinal tissue damage biomarkers for GVHD risk stratification.
Blood Adv. 2022;6(12):3707-3715.
Hendricks A, Müller S, Fassnacht M, Germer CT, Wiegering VA, Wiegering A, Reibetanz J (2022)
Impact of lymphadenectomy on the oncologic outcome of patients with adrenocortical carcinoma - a systematic review and meta-analysis.
Cancers (Basel). 2022;14(2):291.
Kemps PG, Picarsic J, Durham BH, Hélias-Rodzewicz Z, Hiemcke-Jiwa L, van den Bos C, van de Wetering MD, van Noesel CJM, van Laar JAM, Verdijk RM, Flucke UE, Hogendoorn PCW, Woei-A-Jin FJSH, Sciot R, Beilken A, Feuerhake F, Ebinger M, Möhle R, Fend F, Bornemann A, Wiegering V, Ernestus K, Méry T, Gryniewicz-Kwiatkowska O, Dembowska-Baginska B, Evseev DA, Potapenko V, Baykov VV, Gaspari S, Rossi S, Gessi M, Tamburrini G, Héritier S, Donadieu J, Bonneau-Lagacherie J, Lamaison C, Farnault L, Fraitag S, Jullié ML, Haroche J, Collin M, Allotey J, Madni M, Turner K, Picton S, Barbaro PM, Poulin A, Tam IS, El Demellawy D, Empringham B, Whitlock JA, Raghunathan A, Swanson AA, Suchi M, Brandt JM, Yaseen NR, Weinstein JL, Eldem I, Sisk BA, Sridhar V, Atkinson M, Massoth LR, Hornick JL, Alexandrescu S, Yeo KK, Petrova-Drus K, Peeke SZ, Muñoz-Arcos LS, Leino DG, Grier DD, Lorsbach R, Roy S, Kumar AR, Garg S, Tiwari N, Schafernak KT, Henry MM, van Halteren AGS, Abla O, Diamond EL, Emile JF (2022)
ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition.
Blood. 2022;139(2):256-280.
Kleinschmidt K, Lv M, Yanir A, Palma J, Lang P, Eyrich M (2022)
T-Cell-Replete Versus ex vivo T-Cell-Depleted Haploidentical Haematopoietic Stem Cell Transplantation in Children With Acute Lymphoblastic Leukaemia and Other Haematological Malignancies.
Front Pediatr. 2021 Dec 24;9:794541.
Locatelli F, Zugmaier G, Mergen N, Bader P, Jeha S, Schlegel PG, Bourquin JP, Handgretinger R, Brethon B, Rössig C, Kormany WN, Viswagnachar P, Chen-Santel C (2022)
Blood Adv. Blinatumomab in pediatric relapsed/refractory B-cell acute lymphoblastic leukemia: RIALTO expanded access study final analysis.
2022 Feb 8;6(3):1004-1014.
Müller-Scholden L, Deinlein F, Eyrich M, Schlegel PG, Wiegering V, Wölfl M (2022)
Case report: Multifocal EBV-associated diffuse large B-cell lymphoma in a patient with 6-MP associated lymphopenia with TPMT deficiency.
Front Pediatr 2022;10:881612.
Nemes K, Johann PD, Steinbügl M, Gruhle M, Bens S, Kachanov D, Teleshova M, Hauser P, Simon T, Tippelt S, Eberl W, Chada M, Lopez VS, Grigull L, Hernáiz-Driever P, Eyrich M, Pears J, Milde T, Reinhard H, Leipold A, van de Wetering M, Gil-da-Costa MJ, Ebetsberger-Dachs G, Kerl K, Lemmer A, Boztug H, Furtwängler R, Kordes U, Vokuhl C, Hasselblatt M, Bison B, Kröncke T, Melchior P, Timmermann B, Gerss J, Siebert R, Frühwald MC (2022)
Infants and newborns with atypical teratoid rhabdoid tumors (ATRT) and extracranial malignant rhabdoid tumors (eMRT) in the EU-RHAB Registry: A unique and challenging population.
Cancers (Basel) 2022,27;14(9):2185.
Peinelt A, Bremm M, Kreyenberg H, Cappel C, Banisharif-Dehkordi J, Erben S, Rettinger E, Jarisch A, Meisel R, Schlegel PG, Beck O, Bug G, Klusmann JH, Klingebiel T, Huenecke S, Bader P (2022)
Monitoring of Circulating CAR T Cells: Validation of a Flow Cytometric Assay, Cellular Kinetics, and Phenotype Analysis Following Tisagenlecleucel.
Front Immunol. 2022 Mar 2;13:830773.
Reibetanz J, Kelm M, Uttinger KL, Reuter M, Schlegel N, Hankir M, Wiegering V, Germer CT, Fassnacht M, Lock JF, Wiegering A (2022)
Differences in morbidity and mortality between unilateral adrenalectomy for adrenal Cushing's syndrome and bilateral adrenalectomy for therapy refractory extra-adrenal Cushing's syndrome.
Langenbecks Arch Surg. 2022. doi: 10.1007/s00423-022-02568-8.
Thieme A, Maurus K, Ernestus K, Hirsch S, Schramm K, Wirth C, Buck A, Härtel C, Schlegel PG, Eyrich M, Woelfl M, Classen CF, Wiegering VA (2022)
Secondary biphenotypic acute leukemia following Rosai-Dorfman-Disease a coincidence?
Klin Padiatr. 2022;234(3):169-71. doi: 10.1055/a-1699-3016.
Uttinger KL, Riedmeier M, Reibetanz J, Meyer T, Germer CT, Fassnacht M, Wiegering A, Wiegering V (2022)
Adrenalectomies in children and adolescents in Germany - a diagnose related groups based analysis from 2009-2017.
Front Endocrinol (Lausanne). 2022 Jul 27;13:914449.
Wiegering V, Riedmeier M, Thompson LDR, Virgone C, Redlich A, Kuhlen M, Gultekin M, Yalcin B, Decarolis B, Härtel C, Schlegel PG, Fassnacht M, Timmermann B (2022)
Radiotherapy for pediatric adrenocortical carcinoma - review of the literature.
Clin Transl Radiat Oncol. 2022;35:56-63.
Wölfl M, Qayed M, Benitez Carabante MI, Sykora T, Bonig H, Lawitschka A, Diaz-de-Heredia C (2022)
Current prophylaxis and treatment approaches for acute graft-versus-host disease in haematopoietic stem cell transplantation for children with acute lymphoblastic leukaemia.
Front Pediatr. 2022;9:784377.
Yanir A, Schulz A, Lawitschka A, Nierkens S, Eyrich M (2022)
Immune reconstitution after allogeneic haematopoietic cell transplantation: From observational studies to targeted interventions.
Front Pediatr. 2022;9:786017.
2021
Bäuerlein CA, Qureischi M, Mokhtari Z, Tabares P, Brede C, Jordán Garrote AL, Riedel S, Chopra M, Reu S, Mottok A, Arellano-Viera E, Graf C, Kurzwart M, Schmiedgen K, Einsele H, Wölfl M, Schlegel PG, Beilhack A. (2021)
Predictive T-cell surface biomarkers for murine acute graft-versus-host disease.
Front Immunol. 2021;11:593321.
Canzonetta C, Pelosi A, Di Matteo S, Veneziani I, Tumino N, Vacca P, Munari E, Pezzullo M, Theuer C, De Vito R, Pistoia V, Tomao L, Locatelli F, Moretta L, Caruana I*, Azzarone B* (2021)
Identification of neuroblastoma cell lines with uncommon TAZ+/Mesenchymal Stromal Cell phenotype with strong suppressive activity on Natural Killer cells.
J Immunother Cancer. 2021;9(1):e001313.
Fiore PF, Vacca P, Tumino N, Besi F, Pelosi A, Munari E, Marconi M, Caruana I, Pistoia V, Moretta L, Azzarone B (2021)
Wilms' Tumor Primary Cells Display Potent Immunoregulatory Properties on NK Cells and Macrophages.
Cancers (Basel). 2021;13(2):224.
Gerhard-Hartmann E, Wiegering V, Benoit C, Meyer T, Rosenwald A, Maurus K, Ernestus K (2021)
A large retroperitoneal lipoblastoma as an incidental finding: a case report.
BMC Pediatr. 2021;21(1):159.
Hagel C, Sloman V, Mynarek M, Petrasch K, Obrecht D, Kühl J, Deinlein F, Schmid R, von Bueren AO, Friedrich C, Juhnke BO, Gerber NU, Kwiecien R, Girschick H, Höller A, Zapf A, von Hoff K, Rutkowski S (2021)
Refining M1 stage in medulloblastoma: criteria for cerebrospinal fluid cytology and implications for improved risk stratification from the HIT-2000 trial.
Eur J Cancer. 2022 Mar;164:30-38.
Kasikis S, Baz J, Gandhi I, Grupp S, Kitko C, Kowalyk S, Merli P, Morales G, Pulsipher M, Qayed M, Wölfl M, Yanik G, See F Hayes J, Grossman F, Burke E, Young R, Levine JE, Ferrara JLM (2021)
Mesenchymal stromal cell therapy induces high responses and survival in children with steroid refractory GVHD and poor risk biomarkers.
Bone Marrow Transplant. 2021;56(11):2869-2870.
Kleinschmidt K, Lv M, Yanir A, Palma J, Lang P, Eyrich M (2021)
T-cell-replete versus ex vivo T-cell-depleted haploidentical haematopoietic stem cell transplantation in children with acute lymphoblastic leukaemia and other haematological malignancies.
Front Pediatr. 2021;9:794541.
von Lukowicz H, Schlegel PG, Eberl W, von Kries R, Morbach H, Härtel C, Haubitz I, Wiegering VA (2021)
Acute ITP in childhood - do we treat too much? - ESPED evaluation.
Klin Padiatr. 2021;233(3):145-148.
von Lukowicz H, Schlegel PG, Härtel C, Morbach H, Haubitz I, Wiegering V (2021)
ESPED survey on newly diagnosed immune thrombocytopenia in childhood: how much treatment do we give?
Mol Cell Pediatr. 2021;8(1):11.
Marcus A, Schlosser A, Keupp A, Trautwein N, Johann P, Wolfl M, Lager J, Monoranu CM, Walz JS, Henkel LM, Krauss J, Ebinger M, Schuhmann M, Thomale UW, Pietsch T, Klinker E, Schlegel PG, Oyen F, Reisner Y, Rammensee HG, Eyrich M (2021)
Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors.
J Immunother Cancer. 2021;9(10):e003404.
Marissen J, Pagel J, Steinmetz A, Härtel C, Lauten M (2021)
IgG4-related disease and successful treatment with Rituximab in a three-year-old boy.
Ann Hematol Oncol 2021;8(3):1334
Merli P, Ifversen M, Truong T, Marquart HV, Buechner J, Wölfl M, Bader P (2021)
Minimal residual disease prior to and after hematopoietic stem cell transplantation in children and adolescents with acute lymphoblastic leukemia: Which level of negativity is relevant?
Front Pediatr. 2021;9:777108.
Miano M, Eikema DJ, de la Fuente J, Bosman P, Ghavamzadeh A, Smiers F, Sengeløv H, Yesilipek A, Formankova R, Bader P, Díaz Pérez MÁ, Bertrand Y, Niemeyer C, Bron D, Ansari M, Bykova TA, Lanino E, Rovelli A, Gozdzik J, Satti TM, Bodova I, Wölfl M, Rocha VG, Mellgren K, Rascon J, Lange A, Meisel R, Beguin Y, Mozo Y, Kriván G, Sirvent A, Bruno B, Onofrillo D, Risitano AM, Peffault de Latour R, Dufour C (2021)
Stem cell transplantation for diamond-blackfan anemia. A retrospective study on behalf of severe aplastic anemia working party of the European blood and marrow transplantation group (EBMT).
Transplant Cell Ther. 2021;27(3):274.e1-274.e5.
Pelosi A, Fiore PF, Di Matteo S, Veneziani I, Caruana I, Ebert S, Munari E, Moretta L, Maggi E, Azzarone BG (2021)
Pediatric tumors-mediated inhibitory effect on NK cells: the case of Neuroblastoma and Wilms’ tumors.
Cancers. 2021;13(10): 2374.
Riedmeier M, Decarolis B, Haubitz I, Müller S, Uttinger K, Börner K, Reibetanz J, Wiegering A, Härtel C, Schlegel PG, Fassnacht M, Wiegering V (2021)
Adrenocortical carcinoma in childhood: A systematic review.
Cancers (Basel). 2021;13(21):5266
Riedmeier M, Stock A, Krauß J, Sahm F, Jones DTW, Sturm D, Kramm CM, Eyrich M, Härtel C, Schlegel S, Schlegel PG, Monoranu CM, Wiegering V (2021)
Spontaneous regression of a congenital high-grade glioma-a case report.
Neurooncol Adv. 2021;25;3(1):vdab120.
Ruf K, Badran A, Siauw C, Haubitz I, Schlegel PG, Hebestreit H, Härtel C, Wiegering V (2021)
Does allogeneic stem cell transplantation in survivors of pediatric leukemia impact regular physical activity, pulmonary function, and exercise capacity? Mol Cell Pediatr 2021;8(1):16. doi.10.1186/s40348-021-00127-7
Schwinn S, Mokhtari Z, Thusek S, Schneider T, Sirén AL, Tiemeyer N, Caruana I, Miele E, Schlegel PG, Beilhack A, Wölfl M (2021)
Cytotoxic effects and tolerability of gemcitabine and axitinib in a xenograft model for c-myc amplified medulloblastoma.
Scient Rep. 2021;11(1):14062.
Shaim H, Sanabria MH, Basar R, Wang F, Daher M, Zamler D, Gabrusiewicz KR, Gumin J, Miao Q, Dou J, Alsuliman A, Kerbauy LN, Acharya S, Mohanty V, Banerjee P, Mendt M, Liu S, Lu J, Wie J, Fowlkes NW, Gokdemir E, Ensley EL, Kaplan M, Uprety N, Kassab C, Li L, Bdiwi M, Cortes AKN, Ozcan G, Liu E, Yu J, Imahashi N, Muniz-Feliciano L, Marin D, Yu D, Mielke S, Eyrich M, Champlin R, Chen K, Lang F, Shpall E, Heimberger A, Rezvani K (2021)
Inhibition of the αv integrin-TGF-β axis improves natural killer cell function against glioblastoma stem cells.
J Clin Invest. 2021;17:142116.
Springer J, Held J, Mengoli C, Schlegel PG, Gamon F, Träger J, Kurzai O, Einsele H, Loeffler J, Eyrich M (2021)
Diagnostic performance of (1→3)-β-D-Glucan alone and in combination with aspergillus PCR and galactomannan in serum of pediatric patients after allogeneic hematopoietic stem cell transplantation.
J Fungi (Basel). 2021;7(3):238.
Tumino N, Weber G, Besi F, Del Bufalo F, Bertaina V, Paci P, Quatrini L, Antonucci L, Sinibaldi M, Quintarelli C, Maggi E, De Angelis B, Locatelli F, Moretta L, Vacca P*, Caruana I* (2021)
Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastoma.
J Hematol Oncol. 2021;14(1):191.
Zewde M, Morales G, Gandhi I, Özbek U, Aguayo-Hiraldo P, Ayuk F, Baez J, Chanswangphuwana C, Choe H, Defilipp Z, Etra A, Grupp S, Hexner EO, William Hogan, Nora Rebeka Javorniczky, Kasikis S, Kitko CL, Kowalyk S, Merli P, Nakamura R, Qayed M, Reshef R, Rösler W, Schechter T, Schreiner E, Wölfl M, Yanik G, Young R, Levine JE, FerraraJLM, Chen YB (2021)
Evaluation of elafin as a prognostic biomarker in acute graft-vs-host disease.
Transplant Cell Ther. 2021;27(12):988.e1-988.e7.
2020
Auyuk F, Bachmann B, Collier G, Hilgendorf I, Kalusche EM, Kiefer-Trendelenburg T, Krauth K, Kröger N, Lotze C, Lellek H, Mumm A, Orth HB, Schlegel PG, Schmitz J, Schwerdtfeger R, Steimann M, Stehr W, Stöcklein EM, Strohscheer I, Uhrig M (2020)
Inpatient rehabilitation after allogeneic stem cell transplantation.Recommendations for quality assurance.
TumorDiagn u Ther 2020;41:680-694.
Aziz MD, Shah J, Kapoor U, Dimopoulos C, Anand S, Augustine A, Ayuk F, Chaudhry M, Chen YB, Choe HK, Etra A, Gergoudis S, Hartwell MJ, Hexner EO, Hogan WJ, Kitko CL, Kowalyk S, Kröger N, Merli P, Morales G, Nakamura R, Ordemann R, Pulsipher MA, Qayed M, Reshef R, Rösler W, Schechter T, Schreiner E, Srinagesh H, Wölfl M, Wudhikarn K, Yanik G, Young R, Özbek U, Ferrara JLM, Levine JE (2020)
Disease risk and GVHD biomarkers can stratify patients for risk of relapse and nonrelapse mortality post hematopoietic cell transplant.
Leukemia. 2020;34(7):1898-1906. doi: 10.1038/s41375-020-0726-z.
Bäuerlein CA, Qureischi M, Mokhtari Z, Tabares P, Brede C, Jordán Garrote AL, Riedel SS, Chopra M, Reu S, Mottok A, Arellano-Viera E, Graf C, Kurzwart M, Schmiedgen K, Einsele H, Wölfl M, Schlegel PG, Beilhack A (2020)
A T-cell surface marker panel predicts murine acute graft-versus-host disease.
Front Immunol. 2021;11:593321. doi: 10.3389/fimmu.2020.593321.
Bianchi P, Fermo E, Lezon-Geyda K, van Beers EJ, Morton HD, Barcellini W, Glader B, Chonat S, Ravindranath Y, Newburger PE, Kollmar N, Despotovic JM, Verhovsek M, Sharma M, Kwiatkowski JL, Kuo KHM, Wlodarski MW, Yaish HM, Holzhauer S, Wang H, Kunz J, Addonizio K, Al-Sayegh H, London WB, Andres O, van Wijk R, Gallagher PG, Grace RFF (2020)
Genotype-phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency.
Am J Hematol 2020;95(5):472-482.
Desch AK, Hartung K, Botzen A, Brobeil A, Rummel M, Kurch L, Georgi T, Jox T, Bielack S, Burdach S, Classen CF, Claviez A, Debatin KM, Ebinger M, Eggert A, Faber J, Flotho C, Frühwald M, Graf N, Jorch N, Kontny U, Kramm C, Kulozik A, Kühr J, Sykora KW, Metzler M, Müller HL, Nathrath M, Nüßlein T, Paulussen M, Pekrun A, Reinhardt D, Reinhard H, Rössig C, Sauerbrey A, Schlegel PG, Schneider DT, Scheurlen W, Schweigerer L, Simon T, Suttorp M, Vorwerk P, Schmitz R, Kluge R, Mauz-Körholz C, Körholz D, Gattenlöhner S, Bräuninger A (2020)
Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma.
Leukemia. 2020;34(1):151-166. doi: 10.1038/s41375-019-0541-6.
Düver F, Weißbrich B, Eyrich M, Wölfl M, Schlegel PG, Wiegering V (2020)
Viral reactivations following hematopoietic stem cell transplantation in pediatric patients - A single center 11-year analysis.
PLoS One. 2020;15(2):e0228451.
Frühwald MC, Hasselblatt M, Nemes K, Bens S, Steinbügl M, Johann PD, Kerl K, Hauser P, Quiroga E, Solano-Paez P, Biassoni V, Gil-da-Costa MJ, Perek-Polnik M, van de Wetering M, Sumerauer D, Pears J, Stabell N, Holm S, Hengartner H, Gerber NU, Grotzer M, Boos J, Ebinger M, Tippelt S, Paulus W, Furtwängler R, Hernáiz-Driever P, Reinhard H, Rutkowski S, Schlegel PG, Schmid I, Kortmann RD, Timmermann B, Warmuth-Metz M, Kordes U, Gerss J, Nysom K, Schneppenheim R, Siebert R, Kool M, Graf N (2020)
Age and DNA methylation subgroup as potential independent risk factors for treatment stratification in children with atypical teratoid/rhabdoid tumors.
Neuro Oncol. 2020;22(7):1006-1017. doi: 10.1093/neuonc/noz244.
Gierlich P, Lex V, Technau A, Keupp A, Morper L, Glunz A, Sennholz H, Rachor J, Sauer S, Marcu A, Grigoleit GU, Wölfl M, Schlegel PG, Eyrich M (2020)
Prostaglandin E2 in a TLR3- and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8+ T cells.
Cancer Immunol Immunother. 2020;69(6):1029-1042.
Kalwak K, Mielcarek M, Patrick K, Styczynski J, Bader P, Corbacioglu S, Burkhardt B, Sykora KW, Drabko K, Gozdzil J, Fagioli F, Greil J, Gruhn B, Beier R, Locatelli F, Müller I, Schlegel PG, Sedlacek P, Stachel KD, Hemmelmann C, Möller AK, Baumgart J, Vora A (2020)
Treosulfan-fludarabine-thiotepa-based conditioning treatment before allogeneic hematopoietic stem cell transplantation for pediatric patients with hematological malignancies.
Bone Marrow Transplant. 2020. doi: 10.1038/s41409-020-0869-6.
Locatelli F, Zugmaier G, Mergen N, Bader P, Jeha S, Schlegel PG, Bourquin JP, Handgretinger R, Brethon B, Rossig C, Chen-Santel C (2020)
Blinatumomab in pediatric patients with relapsed/refractory acute lymphoblastic leukemia: results of the RIALTO trial, an expanded access study.
Blood Cancer J. 2020;10(7):77. doi: 10.1038/s41408-020-00342-x.
Manukjan G, Wiegering VA, Reindl T, Strauß G, Klopocki E, Schulze H, Andres O (2020)
Novel variants in FERMT3 and RASGRP2-Genetic linkage in Glanzmann-like bleeding disorders.
Pediatr Blood Cancer. 2020;67(2):e28078. doi: 10.1002/pbc.28078.
Metz C, Böckler J, Veldhoen S (2020)
Maligner Keimzelltumor des kleinen Beckens nach Resektion einer Schwanzdarmzyste bei einem weiblichen Säugling.
Rofo. 2020;192(2):185-187.
Mynarek M., von Hoff K., Pietsch T., Ottensmeier H., Warmuth-Metz M., Bison B., Pfister S., Korshunov A., Sharma T., Jaeger N., Ryzhova M., Zheludkova O., Golanov A., Rushing E.J., Hasselbalth M., Koch A., Schüller U., von Deimling A., Sahm F., Sill M., Riemenschneider M.J., Dohmen H., Monoranu C.M., Sommer C., Staszewski O., Mawrin C., Schittenhelm J., Brück W., Filipski K., Hartmann C., Meinhardt M., Pietschmann K., Haberler C., Slavc I., Gerber N.U., Grotzer M., Benesch M., Schlegel P.G., Deinlein F., von Bueren A., Friedrich C., Obrecht D., Fleischhack G., Kwiecien R., Faldum A., Kortmann R.D., Kool M., Rutkowski S (2020)
Non-metastatic medulloblastoma of early childhood: Results from the prospective clinical trial HIT-2000 and an extended validation cohort.
J Clin Oncol. 2020;JCO1903057. doi: 10.1200/JCO.19.03057.
Nemes K, Bens S, Kachanov D, Teleshova M, Hauser P, Simon T, Tippelt S, Woessmann W, Beck O, Flotho C, Grigull L, Driever PH, Schlegel PG, Khurana C, Hering K, Kolb R, Leipold A, Abbink F, Gil-Da-Costa MJ, Benesch M, Kerl K, Lowis S, Marques CH, Graf N, Nysom K, Vokuhl C, Melchior P, Kröncke T, Schneppenheim R, Kordes U, Gerss J, Siebert R, Furtwängler R, Frühwald MC (2020)
Clinical and genetic risk factors define two risk groups of extracranial malignant rhabdoid tumours (eMRT/RTK).
Eur J Cancer. 2020;142:112-122. doi: 10.1016/j.ejca.2020.10.004.
Ottensmeier H, Schlegel PG, Eyrich M, Wolff JE, Juhnke BO, von Hoff K, Frahsek S, Schmidt R, Faldum A, Fleischhack G, von Bueren A, Friedrich C, Resch A, Warmuth-Metz M, Krauss J, Kortmann RD, Bode U, Kühl J, Rutkowski S (2020)
Treatment of children under 4 years of age with medulloblastoma and ependymoma in the HIT2000/HIT-REZ 2005 trials: Neuropsychological outcome 5 years after treatment.
PLoS One. 2020;15(1):e0227693.
Sauer MG, Lang PJ, Albert MH, Bader P, Creutzig U, Eyrich M, Greil J, Gruhn B, Holter W, Klingebiel T, Kremens B, von der Leyen H, Mauz-Körholz C, Meisel R, Mischke K, Müller I, Niemeyer CM, Peters C, Pohler C, Reinhardt D, Burkhardt B, Schlegel PG, Schulz AS, Schrum J, Sedlacek P, Strahm B, Woessmann W, Handgretinger R, Zimmermann M,Borkhardt A (2020)
Hematopoietic stem cell transplantation for children with acute myeloid leukemia-results ofthe AML SCT-BFM 2007 trial.
Leukemia. 2020;34(2):613-624.
Scheer M, Blank B, Bauer S, Vokuhl C, Stegmaier S, Feuchtgruber S, Henssen A, Sparber-Sauer M, Eggert A, Handgretinger R, Pekrun A, Rossig C, Rutkowski S, Schlegel PG, Schrappe M, Simon T, Kazanowska B, Niggli F, Ladenstein R, Ljungman G, Jahnukainen K, Fuchs J, Bielack SS, Koscielniak E, Klingebiel T; Cooperative Weichteilsarkom Studiengruppe [CWS] (2020)
Synovial sacoma disease characteristics and primary tumor sites differ between patent age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS).
J Cancer Res Clin Oncol. 2020; doi: 10.1007/s00432-019-03121-9.
Schlegel S, Hamm H, Reichel A, Kneitz H, Ernestus K, Andres O, Wiegering VG, Eyrich M, Wölfl M, Schlegel PG (2020)
Neonatal Acute Lymphoblastic Leukemia with t(9;11) Translocation Presenting as Blueberry Muffin Baby: Successful Treatment by ALL-BFM Induction Therapy,
Allogeneic Stem Cell Transplantation from an Unrelated Donor, and PCR-MRD-Guided Post-Transplant Follow-Up.
Am J Case Rep. 2020;21:e927153.
Siegmund M, Pagel J, Scholz T, Rupp J, Härtel C, Lauten M (2020)
Pro-inflammatory cytokine ratios determine the clinical course of febrile neutropenia in children receiving chemotherapy.
Mol Cell Pediatr. 2020;7:5 doi: 10.1186/s40348-020-00097-2.
Wustrau K, Greil J, Sykora KW, Albert MH, Burkhardt B, Lang P, Meisel R, Wössmann W, Beier R, Schulz A, Bader P, Chada M, Kühl JS, Schlegel PG, Speckmann C, Gruhn B, Seidel M, Wawer A, Ozga AK, Janka G, Ehl S, Müller I, Lehmberg K (2020)
Risk factors for mixed chimerism in children with hemophagocytic lymphohistiocytosis after reduced toxicity conditioning.
Pediatr Blood Cancer. 2020;e28523. doi: 10.1002/pbc.28523.
2019
Andres O, Loewecke F, Morbach H, Kraus S, Einsele H, Eber S, Speer CP (2019)
Hereditary spherocytosis is associated with decreased pyruvate kinase activity due to impaired structural integrity oft he red blood cell membrane.
Br J Haematol 2019;187(3):386-395.
Althaus K, Zieger B, Bakchoul T, Jurk K on behalf of the THROMKIDplus study group (2019)
Standardization of Light Transmission Aggregometry for Diagnosis of Platelet Disorders: An Inter-Laboratory External
Quality Assessment. Thromb Haemost 2019:119(7):1154-1161.
Banaszek A, Bumm T, Nowotny B, Geis M, Jacob K, Wölfl M, Trebing J, Kouhestani D, Grimmer A, Gogishvili T, Rasche L, Hönemann D, Neuweiler H, Heiby J, Bargou R, Wajant H, Einsele H, Riethmüller G, and Stuhler G (2019)
On-Target Restoration of a Split T Cell Engaging Antibody for Precision Immunotherapy.
Nat Commun. 2019;10(1):5387.
Bonig H, Kuçi Z, Kuçi S, Bakhtiar S, Basu O, Bug G, Dennis M, Greil J, Barta A, Kàllay K, Lang P, Lucchini G, Pol R, Schulz A, Sykora KW, Teichert von Luettichau I, Herter-Sprie G, Uddin M, Jenkin P, Alsultan A, Buechner J, Stein J, Kelemen A, Jarisch A, Soerensen J, Salzmann-Manrique E, Hutter M, Schäfer R, Seifried E, Paneesha S, Novitzky-Basso I, Gefen A, Nevo N, Beultel G, Schlegel PG, Klingebiel T, Bader P (2019)
Children and Adults with Refactory Acute Graft-versus-Host Disease Respond to Treatment with the Mesenchymal Stromal Cell Preparation ”MSC-FFM”-Outcome Report of 92 Patients.
Cells 2019. doi: 10.3390/cells8121577.
Desch AK, Hartung K, Botzen A, Brobeil A, Rummel M, Kurch L, Georgi T, Jox T, Bielack S, Burdach S, Classen CF, Claviez A, Debatin KM, Ebinger M, Eggert A, Faber J, Flotho C, Frühwald M, Graf N, Jorch N, Kontny U, Kramm C, Kulozik A, Kühr J, Sykora KW, Metzler M, Müller HL, Nathrath M, Nüßlein T, Paulussen M, Pekrun A, Reinhardt D, Reinhard H, Rössig C, Sauerbrey A, Schlegel PG, Schneider DT, Scheurlen W, Schweigerer L, Simon T, Suttorp M, Vorwerk P, Schmitz R. Kluge R, Mauz-Körholz C, Körholz D, Gattenlöhner S, Bräuninger A (2019)
Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma.
Leukemia 2019. doi: 10.1038/s41375-019-0541-6.
Eyrich M, Schulze H (2019)
HLA Matching in Pediatric Stem Cell Transplantation.
Transfus Med Hemother 2019;46(5):348-355.
Faraci M, Diesch T, Labopin M, Dalissier A, Lankester A, Gennery A, Sundin M, Uckan-Cetinkaya D, Biering M, Strahm B, Garwer M, Schulz A, Michel G, Giorgiani G, Gruhn B, Locatelli F, Giardino S, Uyttebroeck A, Rialland F, Itäla-Remes M, Dreger P, Shaw PH, Bordon V, Schlegel PG, Mellgren K, Moraleda JM, Patrick K, Schneider P, Jubert C, Lawitschka A, Salooja N, Basak GW, Corbaciuoglu S, Duarte R, Bader P (2019)
Gonadal function after Busulphan compared to Treosulphan in children and adolescents undergoing allogeneic haematopoietic stem cell transplantation. On Behalf of Pediatric and Transplant-Related Complications and Quality of Life EBMT Working Parties.
Biol Blood Marrow Transplant 25(9):1786-1791, 2019.
Fleischhack G, Massimino M, Warmuth-Metz M, Khuhlaeva E, Janssen G, Graf N, Rutkowski S, Beilken A, Schmid I, Biassoni V, Gorelishev SK, Kramm C, Reinhard H, Schlegel PG, Kortmann RD, Reuter D, Bach F, Iznaga-Escobar NE, Bode U (2019)
Nimotuzumab and radiotherapy for treatment of newly diagnosed diffuse intrinsic pontine glioma (DIPG): a phase III clinical study.
J Neurooncol 143(1):107-113, 2019.
Hagemann C, Neuhaus N, Dahlmann M, Kessler AF, Kobelt D, Herrmann P, Eyrich M, Freitag B, Linsenmann T, Monoranu CM, Ernestus RI, Löhr M, Stein U (2019)
Circulating MACC1 Transcripts in Glioblastoma Patients Predict Prognosis and Treatment Response.
Cancers (Basel). 2019 ;10:1484.
Krakow S, Crescimone ML, Bartels C, Wiegering V, Eyrich M, Schlegel PG, Wölfl M.Krakow S, et al (2019)
Re-expression of CD14 in Response to a Combined IL-10/TLR Stimulus Defines Monocyte-Derived Cells With an Immunoregulatory Phenotype.
Front Immunol. 2019 Jun 28;10:1484.
Manukjan G, Eilenberger J, Andres O, Schambeck C, Eber S, Schulze H (2019)
Functional Classification of Paediatric Patients with Non-syndromic Delta-Storage Pool Deficiency.
Hämostaseologie 2019:39(4):383-391.
Marcu A, Eyrich M (2019)
Therapeutic vaccine strategies to induce tumor-specific T-cell responses.
Bone Marrow Transplant. 2019 Aug;54(Suppl 2):806-809.
Miano M, Eikema D, van ‘t Vee PJ, Aljurf M; Maertens J; Öztürk G.; Diaz de Heredia C; Wölfl M; Halkes CJM; Schulz A; Socié G; Vettenranta K; Skorobogatova E; Zecca M; Markiewicz M; Rovira M; Sierra J; Uckan-Cetinkaya D; Antmen A; Dalle J; Hamladji R; Kitra-Roussou V; La Nasa G; Kriván G; Giardino S, Peffault de Latour R; Dufour C (2019)
Stem Cell Transplantation for Congenital Dyserythropoietic Anemia. A retrospective study on behalf of Severe Aplastic Anemia Working Party of the European Blood and Marrow Transplantation Group (EBMT).
Haematologica 2019;104(8):e335-e339. doi: 10.3324/haematol.2018.206623.
Sauer MG, Lang PJ, Albert MH, Bader P, Creutzig U, Eyrich MK, Greil J, Gruhn B, Holter W, Klingebiel T, Kremens B, von der Leyen H, Mauz-Körholz C, Meisel R, Mischke K, Müller I, Niemeyer CM, Peters C, Pohler C, Reinhardt D, Rossig C, Schlegel PG, Schulz AS, Schrum J, Sedlacek P, Strahm B, Woessmann W, Handgretinger R, Zimmermann M, Borkhardt A (2019)
Hematopoietic Stem Cell Transplantation for Children with Acute Myeloid Leukemia- Results of the AML SCT-BFM 2007 trial.
Leukemia, 2019; (9):1786-1791. doi: 10.1016/j.bbmt.2019.05.005. Epub 2019
Scheer M, Vokuhl C, Blank B, Hallmen E, von Kalle T, Münter M, Wessalowski R, Hartwig M, Sparber-Sauer M, Schlegel PG, Kramm CM, Kontny U, Spriewald B, Kegel T, Bauer S, Kazanowska B, Niggli F, Ladenstein R, Ljungman G, Jahnukainen K, Fuchs J, Bielack SS, Klingebiel T, Koscielniak E, Cooperative Weichteilsarkom Studiengruppe [CWS] (2019)
Desmoplastic small round cell tumors: Multimodality treatment and new risk factors.
Cancer Med 2019. doi: 10.1002/cam4.1940, 2019
Schuster SJ, Bishop MR, Tam CS, Waller EK, Borchmann P, McGuirk JP, Jäger U, Jaglowski S, Andreadis C, Westin JR, Fleury I, Bachanova V, Foley SR, Ho PJ, Mielke S, Magenau JM, Holte H, Pantano S, Pacaud LB, Awasthi R, Chu J, Anak Ö, Salles G, Maziarz RT; JULIET Investigators* (2019)
Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma.
N Engl J Med. 2019 Jan 3;380(1):45-56.
*Eyrich M as a JULIET Investigator
Seitz C, Eyrich M, Greil J, Schlegel PG, Feuchtinger P, Bader P, Ebinger M, Schwarze C, Schlegel PG, Schumm M, Handgretinger R, Lang P (2019)
Favorable immune recovery and low rate of GvHD in children transplanted with partially T-cell depleted PBSC grafts.
Bone Marrow Transplantation, 54(1):53-62, 2019
Srinagesh HK, Özbek U, Kapoor U, Ayuk F, Aziz M, Ben-David K, Choe H, DeFilipp ZM, Etra A, Grupp SA, Hartwell MJ, Hexner EO, Hogan WJ, Kitko CL, Kowalyk S, Major-Monfried H, Lin YJ, Mielke S, Merli P, Morales G, Ordemann R, Pulsipher M, Qayed M, Reddy P, Reshef R, Rösler W, Sandhu K, Schechter-Finkelstein T, Shah J, Weber D, Wölfl M, Wudhikarn K, Young R, Levine JE, Ferrara JLM (2019)
The MAGIC Algorithm Probability (MAP) is a validated response biomarker of treatment for acute graft-versus-host disease.
Blood Adv 2019;3(23):4034-4042. doi: 10.1182/bloodadvances.2019000791.
Stein RG, Ebert S, Schlahsa L, Scholz CJ, Braun M, Hauck P, Horn E, Häusler S, Montalban I, Stüber TN, Wölfl M , Dietl J, Diessner J, Wöckel A, Wischhusen J (2019)
Cognate Non-Lytic Interactions between CD8+ T cells and Breast Cancer Cells can induce Cancer Stem Cell-like Properties.
Cancer Res 2019;79(7):1507-1519. doi: 10.1158/0008-5472.
Wiegering V, Eyrich M, Winkler B, Schlegel PG, Wiegering V (2019)
Comparison of Immune Reconstitution After Allogeneic Versus Autologous Stem Cell Transplantation in 182 Pediatric Recipients.
J Pediatr Hematol Oncol. 2019;41(5):e302-e307.
Wiegering V, Keupp A, Frietsch M, Fiessler C, Haas K, Haubitz I, Beyersdorf N, Wölfl M, Schlegel PG, Eyrich M, Wiegering V (2019)
Role of B cells in chronic graft-versus-host disease after allogeneic stem cell transplantation in children and adolescents.
Br J Haematol. 2019;186(5):e133-e137. doi: 10.1111/bjh.15977. Epub 2019 May 28.Br J Haematol. 2019. PMID: 31134622 N
Wiegering V, Peter L, Frietsch M, Schlegel PG, Eyrich M.Wiegering V (2019)
Differences of Immune Reconstitution of Dendritic Cells in Pediatric GvHD Patients After Allogenic Stem Cell Transplantation.
J Pediatr Hematol Oncol. 2019;41(2):e101-e107.
2018
Andres O, Henning K, Strauß G, Pflug A, Manukjan G, Schulze H (2018)
Diagnosis of platelet function disorders: A standardized, rational, and modular flow cytometric approach.
Platelets 2018;29:347-356
Andres O, König EM, Althaus K, Bakchoul T, Bugert P, Eber S, Knöfler R, Kunstmann E, Manukjan G, Meyer O, Strauß G, Streif W, Thiele T, Wiegering V, Klopocki E, Schulze H (2018)
Use of targeted high-throughput sequencing for genetic classification of patients with bleeding diathesis and suspected platelet disorder.
TH Open 2018;2:e445-e454
Gore L, Locatelli F, Zugmaier G, Handgretinger R, O'Brien MM, Bader P, Bhojwani D, Schlegel PG, Tuglus CA, von Stackelberg A (2018)
Survival after blinatumomab treatment in pediatric patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.
Blood Cancer J 2018;8:80
Hierlmeier S, Eyrich M, Wölfl M, Schlegel PG, Wiegering V (2018)
Early and late complications following hematopoietic stem cell transplantation in pediatric patients - A retrospective analysis over 11 years.
PLoS One 2018;13:e0204914
Kuhlen M, Bader P, Sauer M, Albert MH, Gruhn B, Güngör T, Kropshofer G, Lang P, Lawitschka A, Metzler M, Pentek F, Rossig C, Schlegel PG, Schrappe M, Schrum J, Schulz A, Schwinger W, von Stackelberg A, Strahm B, Suttorp M, Luettichau IT, Wößmann W, Borkhardt A, Meisel R, Poetschger U, Glogova E, Peters C (2018)
Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high-risk or relapsed ALL - results of the ALL-SCT 2003 trial.
Br J Haematol 2018;183:104-109
Löhr M, Freitag B, Technau A, Krauss J, Monoranu CM, Rachor J, Lutz MB, Hagemann C, Kessler AF, Linsenmann T, Wölfl M, Ernestus RI, Engelhardt S, Gelbrich G, Schlegel PG, Eyrich M (2018)
High-grade glioma associated immunosuppression does not prevent immune responses induced by therapeutic vaccines in combination with Treg depletion.
Cancer Immunol Immunother 2018;67:1545-1558
Major-Monfried H, Renteria AS, Pawarode A, Reddy P, Ayuk F, Holler E, Efebera YA, Hogan WJ, Wölfl M, Qayed M, Hexner EO, Wudhikarn K, Ordemann R, Young R, Shah J, Hartwell MJ, Chaudhry MS, Aziz M, Etra A, Yanik GA, Kröger N, Weber D, Chen YB, Nakamura R, Rösler W, Kitko CL, Harris AC, Pulsipher M, Reshef R, Kowalyk S, Morales G, Torres I, Özbek U, Ferrara JLM, Levine JE (2018)
MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD.
Blood 2018;131:2846-2855
Mainardi C, Ebinger M, Enkel S, Feuchtinger T, Teltschik HM, Eyrich M, Schumm M, Rabsteyn A, Schlegel P, Seitz C, Schwarze CP, Müller I, Greil J, Bader P, Schlegel PG, Martin D, Holzer U, Döring M, Handgretinger R, Lang P (2018)
CD34+ selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation.
Br J Haematol 2018;180:90-99
Manukjan G, Eilenberger J, Andres O, Schambeck C, Eber S, Schulze H (2018)
Functional classification of pediatric patients with non-syndromic delta-storage pool deficiency.
Hamostaseologie 2018 doi:10.1055/s-0038-1675574
Salzmann-Manrique E, Bremm M, Huenecke S, Stech M, Orth A, Eyrich M, Schulz A, Esser R, Klingebiel T, Bader P, Herrmann E, Koehl U (2018)
Joint modeling of immune reconstitution post haploidentical stem cell transplantation in pediatric patients with acute leukemia comparing CD34+-selected to CD3/CD19-depleted grafts in a retrospective multicenter study.
Front Immunol 2018;9:1841
Schrappe M, Bleckmann K, Zimmermann M, Biondi A, Möricke A, Locatelli F, Cario G, Rizzari C, Attarbaschi A, Valsecchi MG, Bartram CR, Barisone E, Niggli F, Niemeyer C, Testi AM, Mann G, Ziino O, Schäfer B, Panzer-Grümayer R, Beier R, Parasole R, Göhring G, Ludwig WD, Casale F, Schlegel PG, Basso G, Conter V (2018)
Reduced-intensity delayed intensification in standard-risk pediatric acute lymphoblastic leukemia defined by undetectable minimal residual disease: Results of an international randomized trial (AIEOP-BFM ALL 2000).
J Clin Oncol 2018;36:244-253
Seitz CM, Eyrich M, Greil J, Schlegel P, Feuchtinger T, Bader P, Ebinger M, Schwarze CP, Schlegel PG, Schumm M, Handgretinger R, Lang P (2018)
Favorable immune recovery and low rate of GvHD in children transplanted with partially T cell-depleted PBSC grafts.
Bone Marrow Transplant 2019;54:53-62
Sonntag K, Hashimoto H, Eyrich M, Menzel M, Schubach M, Döcker D, Battke F, Courage C, Lambertz H, Handgretinger R, Biskup S, Schilbach K (2018)
Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: A case report.
J Transl Med 2018;16:23
Stromecki M, Tatari N, Morrison LC, Kaur R, Zagozewski J, Palidwor G, Ramaswamy V, Skowron P, Wölfl M, Milde T, Del Bigio MR, Taylor MD, Werbowetski-Ogilvie TE (2018)
Characterization of a novel OTX2-driven stem cell program in Group 3 and Group 4 medulloblastoma.
Mol Oncol 2018;12:495-513
Wiegering V, Eyrich M, Winkler B Schlegel PG (2018)
Comparison of immune reconstitution after allogeneic versus autologous stem cell transplantation in 182 pediatric recipients.
J Pediatr Hematol Oncol 2018 doi: 10.1097/MPH.0000000000001340. [Epub ahead of print]
Wölfl M, Rasche M, Eyrich M, Schmid R, Reinhardt D, Schlegel PG (2018)
Spontaneous reversion of a lineage switch following an initial blinatumomab-induced ALL-to-AML switch in MLL-rearranged infant ALL.
Blood Adv 2018;2:1382-1385
2017
Andres O, Henning K, Strauß G, Pflug A, Manukjan G, Schulze H (2017)
Diagnosis of platelet function disorders: A standardised, rational and modular flow cytometric approach.
Platelets 11:1-10 Epub.
Andres O, Wiegering V, König EM, Schneider AL, Stritt S, Klopocki E, Schulze H (2017)
A novel two-nucleotide deletion in HPS6 affects mepacrine uptake and platelet dense granule secretion in a family with Hermansky-Pudlak syndrome.
Pediatr Blood Cancer 64 (5).
Hartwell MJ, Özbek U, Ernst Holler E, Renteria AS, Major-Monfried H, Reddy P, Aziz M, Hogan WJ, Ayuk F, Efebera YA, Hexner EO, Bunworasate U, Qayed M, Ordemann R, Wölfl M, Mielke S, Pawarode A, Chen YB, Devine S, Harris AC, Jagasia M, Kitko CL, Litzow MR, Kröger N, Locatelli F, Morales G, Reshef RR, Rösler W, Weber D, Wudhikarn K, Yanik GA, Levine JE, Ferrara JLM (2017)
An Early Biomarker Algorithm Predicts Lethal Graft -versus- Host Disease and Survival.
JCI Insights 2(3):e89798.
Hellmann AM, Lother J, Wurster S, Lutz MB, Schmitt AL, Morton CO, Eyrich M, Czakai K, Einsele H, Loeffler J (2017)
Human and Murine Innate Immune Cell Populations Display Common and Distinct Response Patterns during Their In Vitro Interaction with the Pathogenic Mold Aspergillus fumigatus.
Front Immunol 8:1716.
Kredel M, Kunzmann S, Schlegel PG, Wölfl M, Nordbeck P, Bühler C, Lotz C, Lepper P, Wirbelauer J, Roewer N, Muellenbach RM (2017)
Double peripheral veno-arterial cannulation with transseptal left atrial discharge for extracorporeal membrane oxygenation in combined septic and cardiogenic shock.
Am J Case Rep 18:723-727.
Loewecke F, Andres O, Eber S (2017)
Anämiediagnostik ‒ Alte und neue Parameter.
Kinder- und Jugendmedizin 27(2): 93-104.
Reichel A, Hamm H, Wiegering V, Wiewrodt B, Neubauer H, Ernestus K, Winkler B (2017)
Kaposiform hemangioendothelioma with Kasabach-Merritt syndrome: successful treatment with sirolimus.
J Dtsch Dermatol Ges 15(3):329-331. Epub 2017 Feb 21.
No abstract available.
Ribechini E, Hutchinson JA, Hergovits S, Heuer M, Lucas J, Schleicher U, Jordán Garrote AL, Potter SJ, Riquelme P, Brackmann H, Müller N, Raifer H, Berberich I, Huber M, Beilhack A, Lohoff M, Bogdan C, Eyrich M, Hermanns HM, Geissler EK, Lutz MB (2017)
Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function.
Blood Adv 1(14):947-960.
Schulze H, Schlagenhauf A, Manukjan G, Beham-Schmid C, Andres O, Klopocki E, König EM, Haidl H, Panzer S, Althaus K, Muntean WE, Schwinger W, Urban C, Greinacher A, Bakchoul T, Seidel MG (2017)
Recessive grey platelet-like syndrome with unaffected erythropoiesis in the absence of the Splice Isoform GFI1B-p37.
Haematologica. Epub.
2016
Bartelheim K, Nemes K, Seeringer A, Kerl K, Buechner J, Boos J, Graf N, Dürken M, Gerss J, Hasselblatt M, Kortmann RD, Teichert von Luettichau I, Nagel I, Nygaard R, Oyen F, Quiroga E, Schlegel PG, Schmid I, Schneppenheim R, Siebert R, Solano-Paez P, Timmermann B, Warmuth-Metz M, & Frühwald MC (2016)
Improved 6-year overall survival in AT/RT – results of the registry study Rhabdoid 2007.
Cancer Med 5(8):1765-75.
Braun M, Ress ML, Yoo Y-E, Scholz CJ, Eyrich M, Schlegel PG and Wölfl M (2016)
IL 12-mediated sensitizing of T-cell receptor-dependent and –independent tumor cell killing.
Oncoimmunology 5(7):e1188245. doi: 10.1080/2162402X.2016.1188245.
Dietl S, Schwinn S, Dietl S, Riedel S, Deinlein F, Rutkowski S, von Bueren AO, Krauss J, Schweitzer T, Vince GH, Picard D, Eyrich M, Rosenwald A, Ramaswamy V, Taylor MD, Remke M, Monoranu CM, Beilhack A, Schlegel PG, Wölfl M (2016)
MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties.
BMC Cancer 16:115.
Eber S, Andres O (2016)
Anämien.
Monatsschr Kinderheilkd 164(1):59-72.
Eber S. W., Andres O (2016)
Hereditäre Sphärozytose, S1-Leitlinie 025/018.
AWMF 12/2016, 1-26.
Harris AC, Young R, Devine S, Hogan WJ, Ayuk F, Bunworasate U, Chanswangphuwana C, Efebera YA, Holler E, Litzow M, Ordemann R, Qayed M, Renteria AS, Reshef R, Wölfl M, Chen YB, Goldstein S, Jagasia M, Locatelli F, Mielke S, Porter D, Schechter T, Shekhovtsova Z, Ferrara JL, Levine JE (2016)
International, Multicenter Standardization of Acute Graft-versus-Host Disease Clinical Data Collection: A Report from the Mount Sinai Acute GVHD International Consortium.
Biol Blood Marrow Transplant. 22(1):4-10.
Hartz B. Marsh R, Rao K, Henter JI, Jordan M, Filipovich L, Dabder P, Beier R, Burkhardt B, Meisel R, Schulz A, Winkler B, Albert MH, Greil J, Karasu G, Woessmann W, Corbacioglu S, Gruhn B, Holter W, Kühl JS, Lang P, Seidel MG, Veys P, Löfstedt A, Ammann S, Ehl S, Janka G, Müller I, Lehmberg K (2016)
The minimum required level of donor chimerism in hereditary hemophagocytic lymphohistiocytosis.
Blood. 2016;127(25):3281-90.
Loeffler J, Hafner J, Mengoli C, Wirth C, Heussel CP, Löffler C, White PL, Ullmann AJ, Michel D, Wiegering V, Wölfl M, Schlegel PG, Einsele H, Springer J, Eyrich M (2016)
Prospective Biomarker Screening for Diagnosis of Invasive Aspergillosis in High-Risk Pediatric Patients.
J Clin Microbiol. 55(1):101-109.
Müller I, Altherr D, Eyrich M, Flesch B, Friedmann KS, Ketter R, Oertel J, Schwarz EC, Technau A, Urbschat S, Eichler H (2016)
Tumor antigen-specific T cells for immune monitoring of dendritic cell-treated glioblastoma patients.
Cytotherapy 1146-61.
Neubauer H, Wölfl M, Ernestus K (2016)
Dermatom und Diffusion--Diagnostik und Therapiekontrolle eines undifferenzierten embryonalen Sarkoms der Leber.
Rofo 188(4):389-91.
Streng A, Wiegering V, Liese JG (2016)
Varicella in pediatric oncology patients in the post-vaccine era-Analysis of routine hospital data from Bavaria (Germany), 2005-2011.
Pediatric hematology and oncology 33(7-8):468-479.
van Gool SW, Holm S, Rachor J, Adamson L, Technau A, Maass E, Frühwald MC, Schlegel PG, Eyrich M (2016)
Immunotherapy in atypical teratoid-rhabdoid tumors: Data from a survey of the HGG-Immuno Group.
Cytotherapy 18(9):1178-86.
von Bueren AO, Kortmann RD, von Hoff K, Friedrich C, Mynarek M, Müller K, Goschzik T, Zur Mühlen A, Gerber N, Warmuth-Metz M, Soerensen N, Deinlein F, Benesch M, Zwiener I, Kwiecien R, Faldum A, Bode U, Fleischhack G, Hovestadt V, Kool M, Jones D, Northcott P, Kuehl J, Pfister S, Pietsch T, Rutkowski S (2016)
Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters.
J Clin Oncol 34(34):4151-4160.
von Stackelberg A, Locatelli F, Zugmaier G, Handgretinger R, Trippett TM, Rizzari C, Bader P, O'Brien MM, Brethon B, Bhojwani D, Schlegel PG, Borkhardt A, Rheingold SR, Cooper TM, Zwaan CM, Barnette P, Messina C, Michel G, DuBois SG, Hu K, Zhu M, Whitlock JA, Gore L (2016)
Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia.
J Clin Oncol 34(36):4381-4389.
Weber ML, Schneider DT, Offenmüller S, Kaatsch P, Einsiedel HG, Benesch M, Claviez A, Ebinger M, Kramm C, Kratz C, Lawlor J, Leuschner I, Merkel S, Metzler M, Nustede R, Petsch S, Seeger KH, Schlegel PG, Suttorp M, Zolk O, Brecht IB (2016)
Pediatric colorectal carcinoma is associated with excellent outcome in the context of cancer predisposition syndromes.
Ped Blood Cancer 63(4):611-617.
Zipfel J, Eyrich M, Schlegel P-G, Wiegering V (2016)
Disturbed B cell and DC-Homeostasis in Pediatric cGVHD Patients-Cocultivation Experiments and Review of the Literature.
Clin Oncol 1:1097.
Zlamy M, Almanzar G, Parson W, Schmidt C, Leierer J, Weinberger B, Jeller V, Unsinn K, Eyrich M, Würzner R, Prelog M (2016)
Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy.
Immun Ageing 13:3.
2015
Andres O, Schulze H, Speer CP (2015)
Platelets in neonates: central mediators in haemostasis, antimicrobial defence and inflammation.
Thromb Haemost 113(1):3-12.
Chao MM, Ebell W, Bader P, Beier R, Burkhardt B, Feuchtinger T, Handgretinger R, Hanenberg H, Koehl U, Kratz C, Kremens B, Lang P, Meisel R, Mueller I, Roessig C, Sauer M, Schlegel PG, Schulz A, Strahm B, Thol F, Sykora KW (2015)
Consensus of German Transplant Centers on Hematopoietic Stem Cell Transplantation in Fanconi Anemia.
Klin Padiatr 227(3):157-165.
Feucht J, Opherk K, Lang P, Kayser S, Hartl L, Bethge W, Matthes-Martin S, Bader P, Albert MH, Maecker-Kolhoff B, Greil J, Einsele H, Schlegel PG, Schuster FR, Kremens B, Rossig C, Gruhn B, Handgretinger R, Feuchtinger T (2015)
Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT.
Blood 125(12):1986-94.
Hellwig Y, Yoo YE, Reß ML, Andres O, Braun M, Schlegel PG, Wölfl M (2015)
Fulminant skin GvHD with a cytokine pattern resemblant of cytokine release syndrome successfully treated with multimodal immunosuppression including tocilizumab.
Pediatr Blood Cancer 2015 Nov. 62(11):2033-5.
Herbst M, Gazendam R, Reimnitz D, Sawalle-Belohradsky J, Groll A, Schlegel PG, Belohradsky B, Renner E, Klepper J, Grimbacher B, Kuijpers T, Liese J (2015)
Chronic Candida albicans Meningitis in a 4-Year-Old Girl with a Homozygous Mutation in the CARD9 Gene (Q295X).
Pediatr Infect Dis J. 34(9):999-1002.
Li M, Winkler B, Pabst T, Bley T, Köstler H, Neubauer H (2015)
Fast MR Imaging of the Paediatric Abdomen with CAIPIRINHA-Accelerated T1w 3D FLASH and with High-Resolution T2w HASTE: A Study on Image Quality.
Gastroenterol Res Pract 2015:693654.
Nowak J, Löbel U, Wölfl M, Schlegel PG, Warmuth-Metz M (2015)
MRI demyelination pattern and clinical course in a child with cerebral X-linked adrenoleukodystrophy (X-ALD).
Acta Radiol Open 4(4):2047981615573655.
Ottensmeier H, Zimolong B, Wolff JE, Ehrich J, Galley N, von Hoff K, Kuehl J, Rutkowski S (2015)
Neuropsychological short assessment of disease- and treatment-related intelligence deficits in children with brain tumours.
Eur J Paediatr Neurol 19(3):298-307.
Pompe RS, von Bueren AO, Mynarek M, von Hoff K, Friedrich C, Kwiecien R, Treulieb W, Lindow C, Deinlein F, Fleischhack G, Kuehl J, Rutkowski S(2015)
Intraventricular methotrexate as part of primary therapy for children with infant and/or metastatic medulloblastoma: Feasibility, acute toxicity and evidence for efficacy.
Eur J Cancer 2015;51(17):2634-42.
Sandrock-Lang, K., J. Oldenburg, V. Wiegering, S. Halimeh, S. Santoso, K. Kurnik, L. Fischer, D. A. Tsakiris, M. Sigl-Kraetzig, B. Brand, M. Buhrlen, K. Kraetzer, N. Deeg, M. Hund, E. Busse, A. Kahle and B. Zieger (2015)
Characterisation of patients with Glanzmann thrombasthenia and identification of 17 novel mutations.
Thromb Haemost 113:782.
Schuster FR, Stanglmaier M, Woessmann W, Winkler B, Siepermann M, Meisel R, Schlegel PG, Hess J, Lindhofer H, Borkhardt A, Buhmann R (2015)
Immunotherapy with the trifunctional anti-CD20 x anti-CD3 antibody FBTA05 (Lymphomun) in paediatric high-risk patients with recurrent CD20-positive B cell malignancies.
Br J Haematol 169(1):90-102.
Schilbach, K., M. Alkhaled, C. Welker, F. Eckert, G. Blank, H. Ziegler, M. Sterk, F. Müller, K. Sonntag, T. Wieder, H. Braumüller, J. Schmitt, M. Eyrich, S. Schleicher, C. Seitz, A. Erbacher, B.J. Pichler, H. Müller, R. Tighe, A. Lim, S.D. Gillies, W. Strittmatter, M. Röcken (2015)
Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation.
OncoImmunology 4:7, e1014760.
Schmitt J, Eckardt S, Schlegel PG, Sirén AL, Bruttel VS, Mclaughlin KJ, Wischhusen J, Müller AM (2015)
Human parthenogenetic embryonic stem cell-derived neural stem cells express HLA-G and show unique resistance to NK cell-mediated killing.
Mol Med 21:185-96.
Tallen G, Resch A, Calaminus G, Wiener A, Leiss U, Pletschko T, Friedrich C, Langer T, Grabow D, Driever PH, Kortmann RD, Timmermann B, Pietsch T, Warmuth-Metz M, Bison B, Thomale UW, Krauss J, Mynarek M, von Hoff K, Ottensmeier H, Frühwald M, Kramm CM, Temming P, Müller HL, Witt O, Kordes U, Fleischhack G, Gnekow A, Rutkowski S (2015)
Strategies to improve the quality of survival for childhood brain tumour survivors.
Eur J Paediatr Neurol 19(6):619-39.
Veys PA, Nanduri V, Baker KS, He W, Bandini G, Biondi A, Dalissier A, Davis JH, Eames GM, Egeler RM, Filipovich AH, Fischer A, Jürgens H, Krance R, Lanino E, Leung WH, Matthes S, Michel G, Orchard PJ, Pieczonka A, Ringdén O, Schlegel PG, Sirvent A, Vettenranta K, Eapen M (2015)
Haematopoietic stem cell transplantation for refractory Langerhans cell histiocytosis: outcome by intensity of conditioning.
Br J Haematol 169(5):711-8.
von Bueren AO, Friedrich C, von Hoff K, Kwiecien R, Müller K, Pietsch T, Warmuth-Metz M, Hau P, Benesch M, Kuehl J, Kortmann RD, Rutkowski S (2015)
Metastatic medulloblastoma in adults: outcome of patients treated according to the HIT2000 protocol.
Eur J Cancer. 51(16):2434-43.
Wiegering, A., M. Kunz, M. Hussein, I. Klein, V. Wiegering, F. W. Uthe, U. A. Dietz, C. Jurowich, T. Bley, T. Dandekar, C. T. Germer and C. Ritter (2015)
Diagnostic value of preoperative CT scan to stratify colon cancer for neoadjuvant therapy.
Int J Colorectal Dis. 30(8):1067-73.
Wiegering, V. A., I. Klein, C. Wirth, A. Dick, T. Meyer, P. G. Schlegel and A. Wiegering (2015)
Anemia and B Symptoms as Leading Symptoms for a Hepatic Inflammatory Pseudotumor - 2 Case Reports.
Klin Padiatr 227(6-7):363-5.
Winkler, B., J. Aulenbach, T. Meyer, A. Wiegering, M. Eyrich, P. G. Schlegel and V. Wiegering (2015)
Formula-feeding is associated with shift towards Th1 cytokines.
Eur J Nutr 54:129.
Winkler, B., J. Taschik, I. Haubitz, M. Eyrich, P. G. Schlegel and V. Wiegering (2015)
TGFbeta and IL10 have an impact on risk group and prognosis in childhood ALL.
Pediatr Blood Cancer 62:72.
Zils K, Klingebiel T, Behnisch W, Mueller HL, Schlegel PG, Fruehwald M, Suttorp M, Simon T, Werner M, Bielack S (2015)
Osteosarcoma in patients with Rothmund-Thomson syndrome.
Pediatr Hematol Oncol. 32(1):32-40.
2014
Benesch M, Bartelheim K, Fleischhack G, Gruhn B, Schlegel PG, Witt O, Stachel KD, Hauch H, Urban C, Quehenberger F, Massimino M, Pietsch T, Hasselblatt M, Giangaspero F, Kordes U, Schneppenheim R, Hauser P, Klingebiel T, Frühwald MC (2014)
High-dose chemotherapy (HDCT) with auto-SCT in children with atypical teratoid/rhabdoid tumors (AT/RT): a report from the European Rhabdoid Registry (EU-RHAB).
Bone Marrow Transplant 49(3):370-5.
Braun M, Wölfl M, Wiegering V, Winkler B, Ertan K, Bald R, Schwarz K, Heimpel H, Eyrich M, Schlegel PG (2014)
Successful treatment of an infant with CDA type II by intrauterine transfusions and postnatal stem cell transplantation.
Pediatr Blood Cancer 61:743-5.
Chandran PA, Keller A, Weinmann L, Seida AA, Braun M, Andreev K, Fischer B, Horn E, Schwinn S, Junker M, Houben R, Dombrowski Y, Dietl J, Finotto S, Wölfl M, Meister G, Wischhusen J (2014)
The TGF-β-inducible miR-23a cluster attenuates IFN-γ levels and antigen-specific cytotoxicity in human CD8⁺ T cells.
J Leukoc Biol 2014 Oct;96(4):633-45.
Eyrich M (2014)
Case 19: A one year old boy with SCID. In: Kröger, N, Aversa F (eds): 34 successful treatment reports.
Thieme 2014.
Eyrich, M., S.C. Schreiber, J. Rachor, J. Krauß , F. Pauwels, J. Hain, M. Wölfl, M.B. Lutz, S. de Vleeschouwer, P.G. Schlegel, S.W. Van Gool (2014)
Development and validation of a fully GMP-compliant production process of autologous, tumor-lysate pulsed dendritic cells.
Cytotherapy 16:946.
Fink S, Kunzmann S, Andres O, Eyrich M, Wiegering V (2014)
Haemophilia in extreme immature preterm infants: increased risk for intracranial haemorrhage?
J Matern Fetal Neonatal Med 27:621-4.
Gerber NU, von Hoff K, Resch A, Ottensmeier H, Kwiecien R, Faldum A, Matuschek C, Hornung D, Bremer M, Benesch M, Pietsch T, Warmuth-Metz M, Kuehl J, Rutkowski S, Kortmann RD (2014)
Treatment of children with central nervous system primitive neuroectodermal tumors/pinealoblastomas in the prospective multicentric trial HIT 2000 using hyperfractionated radiation therapy followed by maintenance chemotherapy.
Int J Radiat Oncol Biol Phys 89(4):863-71.
Güngör T, Teira P, Slatter M, Stussi G, Stepensky P, Moshous D, Vermont C, Ahmad I, Shaw PJ, da Cunha JM, Schlegel PG, Hough R, Fasth A, Kentouche K, Gruhn B, Fernandes JF, Lachance S, Bredius R, Resnick IB, Belohradsky BH, Gennery A, Fischer A, Gaspar HB, Schanz U, Seger R, Rentsch K, Veys P, Haddad E, Albert MH, Hassan M; on behalf of the Inborn Errors Working Party of the European Society for Blood and Marrow Transplantation (2014)
Reduced-intensity conditioning and HLA-matched haemopoietic stem-cell transplantation in patients with chronic granulomatous disease: a prospective multicentre study.
Lancet 383:436-48.
Hassold N, Warmuth-Metz M, Winkler B, Kreissl MC, Ernestus K, Beer M, Neubauer H (2014)
Hit the mark with diffusion-weighted imaging: metastases of rhabdomyosarcoma to the extraocular eye muscles.
BMC Pediatr 14:57.
Illhardt T, Ebinger M, Schwarze CP, Feuchtinger T, Furtwängler R, Schlegel PG, Klingebiel T, Greil J, Beck JF, Handgretinger R, Lang P (2014)
Children with relapsed or refractory nephroblastoma: favorable long-term survival after high-dose chemotherapy and autologous stem cell transplantation.
Klin Padiatr 226(6-7):351-6.
Schuster FR, Stanglmaier M, Woessmann W, Winkler B, Siepermann M, Meisel R, Schlegel PG, Hess J, Lindhofer H, Borkhardt A, Buhmann R (2014)
Immunotherapy with the trifunctional anti-CD20 x anti-CD3 antibody FBTA05 (Lymphomun) in paediatric high-risk patients with recurrent CD20-positive B cell malignancies. Br J Haematol.
Epub ahead of print.
Streif, W., R. Knofler, W. Eberl, O. Andres, T. Bakchoul, F. Bergmann, K. Beutel, R. Dittmer, S. Gehrisch, S. Gottstein, S. Halimeh, J. Haselbock, W. A. Hassenpflug, S. Heine, S. Holzhauer, S. King, C. M. Kirchmaier, M. Krause, W. Kreuz, W. Losche, R. Mahnel, M. Maurer, A. Nimtz-Talaska, M. Olivieri, H. Rott, M. Schambeck Ch, A. Schedel, F. H. Schilling, M. Schmugge, R. Schneppenheim, U. Scholz, T. Scholz, H. Schulze, A. Siegemund, G. Strauss, K. W. Sykora, C. Wermes, V. Wiegering, I. Wieland, B. Zieger and R. B. Zotz (2014)
Therapy of inherited diseases of platelet function. Interdisciplinary S2K guideline of the Permanent Paediatric Committee of the Society of Thrombosis and Haemostasis Research (GTH e. V.).
Hamostaseologie 34:269.
Watzka, M., C. Geisen, M. Scheer, R. Wieland, V. Wiegering, T. Dorner, H. J. Laws, F. Gumruk, S. Hanalioglu, S. Unal, D. Albayrak and J. Oldenburg (2014)
Bleeding and non-bleeding phenotypes in patients with GGCX gene mutations.
Thromb Res 134:856.
Wiegering, A., F. Endter, V. A. Wiegering, C. T. Germer and J. Maroske (2014)
Bowl obstruction due to an incomplete obliterated omphalomesenteric duct.
Klin Padiatr 226:80.
Wiegering, V., J. Frank, S. Freudenberg, H. Morbach, P. G. Schlegel, M. Eyrich and B. Winkler (2014)
Impaired B-cell reconstitution in children after chemotherapy for standard or medium risk acute precursor B-lymphoblastic leukemia.
Leuk Lymphoma 55:870.
Wiegering V, Schmid S, Andres O, Wirth C, Wiegering A, Meyer T, Winkler B, Schlegel PG, Eyrich M (2014)
Thrombosis as a complication of central venous access in pediatric patients with malignancies: a 5-year single-center experience.
BMC Hematol 14(1):18.
Wölfl M, Greenberg PD (2014)
Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells.
Nat Protoc 2014 Apr;9(4):950-66.
Ziegler S, Skibbe K, Walker A, Ke X, Heinemann FM, Heinold A, Mok JY, van Esch WJ, Yang D, Wölfl M, Timm J (2014)
Impact of sequence variation in a dominant HLA-A*02-restricted epitope in hepatitis C virus on priming and cross-reactivity of CD8+ T cells.
J Virol 2014 Oct;88(19):11080-90.
2013
Andres O, Strehl K, Kölsch U, Kunzmann S, Lebrun AH, Stroh T, Schwarz K, Morbach H, von Bernuth H, Liese J (2013)
Even in pneumococcal sepsis CD62L shedding on granulocytes proves to be a reliable functional test for the diagnosis of interleukin-1 receptor-associated kinase-4 deficiency.
Pediatr Infect Dis J 32:1017-9.
Bäuerlein CA, Riedel SS, Baker J, Brede C, Garrote AL, Chopra M, Ritz M, Beilhack GF, Schulz S, Zeiser R, Schlegel PG, Einsele H, Negrin RS, Beilhack A (2013)
A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model.
BMC Med 21;11:134.
Beier R, Albert MH, Bader P, Borkhardt A, Creutzig U, Eyrich M, Ehlert K, Gruhn B, Greil J, Handgretinger R, Holter W, Klingebiel T, Kremens B, Lang P, Mauz-Körholz C, Meisel R, Müller I, Peters C, Reinhardt D, Sedlacek P, Schulz A, Schuster FR, Schrauder A, Strahm B, Sykora KW, Wössmann W, Zimmermann M, Sauer MG (2013)
Allo-SCT using BU, CY and melphalan for children with AML in second CR.
Bone Marrow Transplant 48:651-6.
Beier R, Schulz A, Hönig M, Eyrich M, Schlegel PG, Holter W, Stachel KD, Ehlert K, Greil J, Nürnberger W, Wössmann W, Bader P, Urban C, Müller I, Suttorp M, Sauer M, Gruhn B, Meisel R, Zimmermann M, Sykora KW (2013)
Long-term follow-up of children conditioned with Treosulfan: German and Austrian experience.
Bone Marrow Transplant 48:491-501.
Brehm C, Huenecke S, Pfirrmann V, Rossig C, Mackall CL, Bollard CM, Gottschalk S, Schlegel PG, Klingebiel T, Bader P (2013)
Highlights of the third International Conference on Immunotherapy in Pediatric Oncology.
Pediatr Hematol Oncol 30:349-66.
Chapuis AG, Ragnarsson GB, Nguyen HN, Chaney CN, Pufnock JS, Schmitt TM, Duerkopp N, Roberts IM, Pogosov GL, Ho WY, Ochsenreither S, Wölfl M, Bar M, Radich JP, Yee C, Greenberg PD (2013)
Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients.
Sci Transl Med 5:174ra27.
Dantonello TM, Int-Veen C, Schuck A, Seitz G, Leuschner I, Nathrath M, Schlegel PG, Kontny U, Behnisch W, Veit-Friedrich I, Kube S, Hallmen E, Kazanowska B, Ladenstein R, Paulussen M, Ljungman G, Bielack SS, Klingebiel T, Koscielniak E; Cooperative Weichteilsarkom Studiengruppe (2013)
Survival following disease recurrence of primary localized alveolar rhabdomyosarcoma.
Pediatr Blood Cancer 60:1267-73.
Eyrich M, Rachor J, Schreiber SC, Wölfl M, Schlegel PG (2013)
Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives.
Front Pediatr 10;1:12.
Friedrich C, von Bueren AO, von Hoff K, Gerber NU, Ottensmeier H, Deinlein F, Benesch M, Kwiecien R, Pietsch T, Warmuth-Metz M, Faldum A, Kuehl J, Kortmann RD, Rutkowski S (2013)
Treatment of young children with CNS-primitive neuroectodermal tumors/pineoblastomas in the prospective multicenter trial HIT 2000 using different chemotherapy regimens and radiotherapy. Neuro Oncol 15:224-34.
Friedrich C, von Bueren AO, von Hoff K, Kwiecien R, Pietsch T, Warmuth-Metz M, Hau P, Deinlein F, Kuehl J, Kortmann RD, Rutkowski S (2013)
Treatment of adult nonmetastatic medulloblastoma patients according to the paediatric HIT 2000 protocol: a prospective observational multicentre study.
Eur J Cancer 49:893-903.
Hofmann M, Schlegel PG, Hippert F, Schmidt P, von-Schweinitz D, Leuschner I, Göbel U, Calaminus G, Schneider DT; MAKEI study group (2013)
Testicular sex cord stromal tumors: analysis of patients from the MAKEI study.
Pediatr Blood Cancer 60:1651-5.
Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM. (2013) International Cancer Genome Consortium PedBrain Tumor Project (2013)
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.
Nat Genet 45:927-32.
Shmukler BE, Mukodzi S, Andres O, Eber S, Alper SL (2013)
Autosomal dominant overhydrated stomatocytosis associated with the heterozygous RhAG mutation F65S: a case of missed heterozygosity due to allelic dropout.
Br J Haematol 161:602-4.
Tan SM, Kapp M, Flechsig C, Kapp K, Rachor JE, Eyrich M, Loeffler J, Einsele H, Grigoleit GU. (2013)
Stimulating surface molecules, Th1-polarizing cytokines, proven trafficking--a new protocol for the generation of clinical-grade dendritic cells.
Cytotherapy 15:492-506.
Wiegering V, Andres O, Schlegel PG, Deinlein F, Eyrich M, Sturm A (2013) Hyperfibrinolysis and acquired factor XIII deficiency in newly diagnosed pediatric malignancies.
Haematologica 98:e90-1.
Wiegering V, Schlegel PG, Winkler B (2013)
Immune function in newly diagnosed children with malignancy.
J Pediatr Hematol Oncol 34:559-64.
Wiegering V, Sauer K, Winkler B, Eyrich M, Schlegel PG (2013)
Indication for allogeneic stem cell transplantation in Glanzmann's thrombasthenia.
Hamostaseologie 33:305-12.
Wiegering V, Winkler B, Haubitz I, Wölfl M, Schlegel PG, Eyrich M (2013)
Lower TGFß serum levels and higher frequency of IFNγ-producing T cells during early immune reconstitution in surviving children after allogeneic stem cell transplantation.
Pediatr Blood Cancer 60:121-8.
Winkler B, Kuhn S, Kunzmann S, Ruf K, Wiegering V, Schlegel PG. (2013) Severe Hypertriglyceridemia in a 6 Year Old Boy with ALL Relapse: Successfully Treated with Plasmapheresis. Klin Padiatr 225:364-365.
Wölfl M, Langhammer F, Wiegering V, Eyrich M, Schlegel PG (2013)
Dasatinib medication causing profound immunosuppression in a patient after haploidentical SCT: functional assays from whole blood as diagnostic clues.
Bone Marrow Transplant 48:875-7.
Wölfl M, Schwinn S, Yoo YE, Reß ML, Braun M, Chopra M, Schreiber SC, Ayala VI, Ohlen C, Eyrich M, Beilhack A, Schlegel PG (2013)
Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.
Blood 122:1203-13.
2012
Corbacioglu S, Cesaro S, Faraci M, Valteau-Couanet D, Gruhn B, Rovelli A, Boelens JJ, Hewitt A, Schrum J, Schulz AS, Müller I, Stein J, Wynn R, Greil J, Sykora KW, Matthes-Martin S, Führer M, O'Meara A, Toporski J, Sedlacek P, Schlegel PG, Ehlert K, Fasth A, Winiarski J, Arvidson J, Mauz-Körholz C, Ozsahin H, Schrauder A, Bader P, Massaro J, D'Agostino R, Hoyle M, Iacobelli M, Debatin KM, Peters C, Dini G (2012)
Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haematopoietic stem-cell transplantation : an open-label, phase 3, randomised controlled trial.
Lancet 1301-1309.
Gerber NU, von Hoff K, von Bueren AO, Treulieb W, Deinlein F, Benesch M, Zwiener I, Soerensen N, Warmuth-Metz M, Pietsch T, Mittler U, Kuehl J, Kortmann RD, Grotzer MA, Rutkowski S (2012)
A long duration of the prediagnostic symptomatic interval is not associated with an unfavourable prognosis in childhood medulloblastoma.
Eur J Cancer 48:2028-36.
Kapp M, Grigoleit GU, Dietz UA, Wiegering V, Stuhler G, Schlegel N, Einsele H, Mielke S, Germer CT, Strauss A (2012)
Prevention of major infectious complications by pre-emptive enterostomy in patients awaiting allogeneic stem cell transplantation.
Int J Colorectal Dis 27:1683-1685.
Kronik N, Kogan Y, Schlegel PG, Wölfl M (2012)
Improving T cell immunotherapy for melanoma through a mathematically motivated strategy: efficacy in numbers?
J of Immunotherapy 35:116-124.
Neubauer H, Evangelista L, Hassold N, Winkler B, Schlegel PG, Köstler H, Hahn D, Beer M (2012)
Diffusion-weighted MRI for detection and differentiation of musculoskeletal tumor-like lesions in pediatric patients.
World J Pediatr 8(4):342-49.
Ronceray L, Pötschger U, Janka G, Gadner H, Minkov M; German Society for Pediatric Hematology and Oncology, Langerhans Cell Histiocytosis Study Group (2012)
Pulmonary involvement in pediatric-onset multisystem Langerhans cell histiocytosis: effect on course and outcome.
J Pediatr 161(1):129-33.e1-3.
Sandrock K, Halimeh S, Wiegering V, Kappert G, Sauer K, Deeg N, Busse E, Zieger B (2012)
Homozygous point mutations in platelet glycoprotein ITGA2B gene as cause of Glanzmann thrombasthenia in 2 families.
Klin Pädiatr 224:174-178.
Slee RB, Steiner CM, Herbert BS, Vance GH, Hickey RJ, Schwarz T, Christan S, Radovich M, Schneider BP, Schindelhauer D, Grimes BR (2012)
Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability.
Oncogene 31:3244-53.
Styczynski J, Balduzzi A, Gil L, Labopin M, Hamladji RM, Marktel S, Yesilipek MA, Fagioli F, Ehlert K, Matulova M, Dalle JH, Wachowiak J, Miano M, Messina C, Diaz MA, Vermylen C, Eyrich M, Badell I, Dreger P, Gozdzik J, Hutt D, Rascon J, Dini G, Peters C (2012)
Risk of complications during hematopoietic stem cell collection in pediatric sibling donors: a prospective EBMT-PDWP study.
Blood 119:2935-42.
Thiel U, Wolf P, Wawer A, Blaeschke F, Grunewald TG, von Lüttichau IT, Klingebiel T, Bader P, Borkhardt A, Laws HJ, Handgretinger R, Lang P, Schlegel PG, Eyrich M, Gruhn B, Ehninger G, Koscielniak E, Klein C, Sykora KW, Holler E, Mauz-Körholz C, Woessmann W, Richter GH, Schmidt AH, Peters C, Dirksen U, Jürgens H, Bregni M, Burdach (2012)
S. Human leukocyte antigen distribution in German Caucasians with advanced Ewing’s sarcoma.
Klin Pädiatr 224:353-358.
Wiegering V, Schlegel PG, Winkler B (2012)
Immune function in newly diagnosed children with malignancy.
J Pediatr Hematol Oncol, 34:559-564.
Wolff B, Ng A, Roth D, Parthey K, Warmuth-Metz M, Eyrich M, Kordes U, Kortmann R, Pietsch T, Kramm C, Wolff JE (2012)
Pediatric high grade glioma of the spinal cord: results of the HIT-GBM database.
J Neurooncol 107:139-46.
2011
Eyrich M, Schreiber SC, Wollny G, Ziegler H, Schlenker R, Koch-Buttner K, Wolfl M, Schlegel PG, Schilbach K (2011)
Pre-differentiated human committed T-lymphoid progenitors promote peripheral T-cell re-constitution after stem cell transplantation in immunodeficient mice.
Eur J Immunol 41:3596-3603.
Gerber NU, von Hoff K, von Bueren AO, Treulieb W, Warmuth-Metz M, Pietsch T, Soerensen N, Faldum A, Emser A, Schlegel PG, Deinlein F, Kortmann RD, Rutkowski S (2011)
Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006.
J Neurooncol 102:459-469.
Kreyenberg H, Jarisch A, Bayer C, Schuster B, Willasch A, Strahm B, Kremens B, Gruhn B, Schrauder A, Burdach S, Fuhrer M, Rossig C, Kabisch H, Schlegel PG, Stachel D, Beck JF, Mauz-Koerholz C, Chung TL, Holler E, Klingebiel T, Bader P (2011)
NOD2/CARD15 gene polymorphisms affect outcome in pediatric allogeneic stem cell transplantation.
Blood 118:1181-1184.
Lang P, Pfeiffer M, Teltschik HM, Schlegel P, Feuchtinger T, Ebinger M, Klingebiel T, Bader P, Schlegel PG, Beck J, Greil J, Handgretinger R (2011)
Natural killer cell activity influences outcome after T cell depleted stem cell transplantation from matched unrelated and haploidentical donors.
Best Pract Res Clin Haematol 24:403-411.
Pufnock JS, Cigal M, Rolczynski LS, Andersen-Nissen E, Wolfl M, McElrath MJ, Greenberg PD (2011)
Priming CD8+ T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8+ T cells retaining CD28.
Blood 117: 6542-6551.
Rettinger E, Willasch AM, Kreyenberg H, Borkhardt A, Holter W, Kremens B, Strahm B, Woessmann W, Mauz-Koerholz C, Gruhn B, Burdach S, Albert MH, Schlegel PG, Klingebiel T, Bader P (2011)
Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation.
Blood 118:5681-5688.
Schlegel P, Teltschik HM, Pfeiffer M, Handgretinger R, Schumm M, Koscielniak E, Feuchtinger T, Klingebiel T, Bader P, Schlegel PG, Greil J, Lang P (2011)
Long-term IL-2 therapy after transplantation of T cell depleted stem cells from alternative donors in children.
Best Pract Res Clin Haematol 24:443-452.
Thiel U, Wawer A, Wolf P, Badoglio M, Santucci A, Klingebiel T, Basu O, Borkhardt A, Laws HJ, Kodera Y, Yoshimi A, Peters C, Ladenstein R, Pession A, Prete A, Urban EC, Schwinger W, Bordigoni P, Salmon A, Diaz MA, Afanasyev B, Lisukov I, Morozova E, Toren A, Bielorai B, Korsakas J, Fagioli F, Caselli D, Ehninger G, Gruhn B, Dirksen U, Abdel-Rahman F, Aglietta M, Mastrodicasa E, Torrent M, Corradini P, Demeocq F, Dini G, Dreger P, Eyrich M, Gozdzik J, Guilhot F, Holler E, Koscielniak E, Messina C, Nachbaur D, Sabbatini R, Oldani E, Ottinger H, Ozsahin H, Schots R, Siena S, Stein J, Sufliarska S, Unal A, Ussowicz M, Schneider P, Woessmann W, Jurgens H, Bregni M, Burdach S (2011)
No improvement of survival with reduced- versus high-intensity conditioning for allogeneic stem cell transplants in Ewing tumor patients.
Ann Oncol 22:1614-1621.
von Bueren AO, von Hoff K, Pietsch T, Gerber NU, Warmuth-Metz M, Deinlein F, Zwiener I, Faldum A, Fleischhack G, Benesch M, Krauss J, Kuehl J, Kortmann RD, Rutkowski S (2011)
Treatment of young children with localized medulloblastoma by chemotherapy alone: results of the prospective, multicenter trial HIT 2000 confirming the prognostic impact of histology.
Neuro Oncol 13:669-679.
von Bueren AO, Warmuth-Metz M, Schlegel PG, Soerensen N, Krauss J, Roggendorf W, Pietsch T, Feiden W, Graf N, Pohl F, Flentje M, Kuehl J, Rutkowski S (2011)
Late complete remission of supratentorial primitive neuroectodermal tumor (CNS-PNET) after multiple relapses.
Pediatr Blood Cancer 56:503-505.
von Hoff K, Hinkes B, Dannenmann-Stern E, von Bueren AO, Warmuth-Metz M, Soerensen N, Emser A, Zwiener I, Schlegel PG, Kuehl J, Fruhwald MC, Kortmann RD, Pietsch T, Rutkowski S (2011)
Frequency, risk-factors and survival of children with atypical teratoid rhabdoid tumors (AT/RT) of the CNS diagnosed between 1988 and 2004, and registered to the German HIT database.
Pediatr Blood Cancer 57:978-985.
Wiegering V, Eyrich M, Rutkowski S, Wolfl M, Schlegel PG, Winkler B (2011)
TH1 predominance is associated with improved survival in pediatric medulloblastoma patients.
Cancer Immunol Immunother 60:693-703.
Wiegering V, Schick J, Beer M, Weissbrich B, Gattenlohner S, Girschick HJ, Liese J, Schlegel PG, Eyrich M (2011)
Varicella-zoster virus infections in immunocompromised patients - a single centre 6-years analysis.
BMC Pediatr 11:31.
Wiegering V, Winkler B, Langhammer F, Wolfl M, Wirbelauer J, Sauer K, Kobsar A, Meyer T, Strauss A, Bakchoul T, Eyrich M, Schlegel PG (2011)
Allogeneic hematopoietic stem cell transplantation in Glanzmann thrombasthenia complicated by platelet alloimmunization.
Klin Padiatr 223:173-175.
Wölfl M, Merker K, Morbach H, Van Gool SW, Eyrich M, Greenberg PD, Schlegel PG (2011)
Primed tumor-reactive multifunctional CD62L+ human CD8+ T cells for immunotherapy.
Cancer Immunol Immunother 60:173-18.
2010
Benesch M, Weber-Mzell D, Gerber NU, von Hoff K, Deinlein F, Krauss J, Warmuth-Metz M, Kortmann RD, Pietsch T, Driever PH, Quehenberger F, Urban C, Rutkowski S (2010)
Ependymoma of the spinal cord in children and adolescents: a retrospective series from the HIT database.
J Neurosurg Pediatr 6:137-144.
Coosemans A, Wolfl M, Berneman ZN, Van Tendeloo V, Vergote I, Amant F, Van Gool SW (2010)
Immunological response after therapeutic vaccination with WT1 mRNA-loaded dendritic cells in end-stage endometrial carcinoma.
Anticancer Res 30:3709-3714.
Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Sakamoto KM, Gorr TA, Mehta P, Schmid I, Kropshofer G, Corbacioglu S, Lang PJ, Klein C, Schlegel PG, Heinzmann A, Schneider M, Stary J, van den Heuvel-Eibrink MM, Hasle H, Locatelli F, Sakai D, Archambeault S, Chen L, Russell RC, Sybingco SS, Ohh M, Braun BS, Flotho C, Loh ML (2010)
Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.
Nat Genet 42:794-800.
Rutkowski S, von Hoff K, Emser A, Zwiener I, Pietsch T, Figarella-Branger D, Giangaspero F, Ellison DW, Garre ML, Biassoni V, Grundy RG, Finlay JL, Dhall G, Raquin MA, Grill J (2010)
Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis.
J Clin Oncol 28:4961-4968.
Schlegel PG, Eyrich M, Kramm C, van Gool S (2010)
Tumor vaccination for high-grade glioma.
Pediatr Blood Cancer 55:1437.
von Hoff K, Hartmann W, von Bueren AO, Gerber NU, Grotzer MA, Pietsch T, Rutkowski S (2010)
Large cell/anaplastic medulloblastoma: outcome according to myc status, histopathological, and clinical risk factors.
Pediatr Blood Cancer 54:369-376.
Wolff JE, Driever PH, Erdlenbruch B, Kortmann RD, Rutkowski S, Pietsch T, Parker C, Metz MW, Gnekow A, Kramm CM (2010)
Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol.
Cancer 116:705-12.
Wolfl M, Merker K, Morbach H, Van Gool SW, Eyrich M, Greenberg PD, Schlegel PG (2010)
Primed tumor-reactive multifunctional CD62L+ human CD8+ T cells for immunotherapy.
Cancer Immunol Immunother 60:173-186.
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