Publikationen der AG Eyrich

Gierlich P, Lex V, Technau A, Keupp A, Morper L, Glunz A, Sennholz H, Rachor J, Sauer S, Marcu A, Grigoleit GU, Wölfl M, Schlegel PG, Eyrich M (2020)
Prostaglandin E2 in a TLR3- and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8+ T cells.
Cancer Immunol Immunother. 2020 Jun;69(6):1029-1042.

Sauer MG, Lang PJ, Albert MH, Bader P, Creutzig U, Eyrich M, Greil J, Gruhn B, Holter W, Klingebiel T, Kremens B, von der Leyen H, Mauz-Körholz C, Meisel R, Mischke K, Müller I, Niemeyer CM, Peters C, Pohler C, Reinhardt D, Burkhardt B, Schlegel PG, Schulz AS, Schrum J, Sedlacek P, Strahm B, Woessmann W, Handgretinger R, Zimmermann M, Borkhardt A (2020)
Hematopoietic stem cell transplantation for children with acute myeloid leukemia-results of the AML SCT-BFM 2007 trial.
Leukemia. 2020 Feb;34(2):613-624.

Krakow S, Crescimone ML, Bartels C, Wiegering V, Eyrich M, Schlegel PG, Wölfl M (2019)
Re-expression of CD14 in Response to a Combined IL-10/TLR Stimulus Defines Monocyte-Derived Cells With an Immunoregulatory Phenotype. 
Front Immunol. 2019 Jun 28;10:1484.

Wiegering V, Keupp A, Frietsch M, Fiessler C, Haas K, Haubitz I, Beyersdorf N, Wölfl M, Schlegel PG, Eyrich M (2019)
Role of B cells in chronic graft-versus-host disease after allogeneic stem cell transplantation in children and adolescents. 
Br J Haematol. 2019 Sep;186(5):e133-e137.

Schuster SJ, Bishop MR, Tam CS, Waller EK, Borchmann P, McGuirk JP, Jäger U, Jaglowski S, Andreadis C, Westin JR, Fleury I, Bachanova V, Foley SR, Ho PJ, Mielke S, Magenau JM, Holte H, Pantano S, Pacaud LB, Awasthi R, Chu J, Anak Ö, Salles G, Maziarz RT; JULIET Investigators* (2019)
Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma.
N Engl J Med. 2019 Jan 3;380(1):45-56.
*Eyrich M as a JULIET Investigator

Eyrich M, Schulze H (2019)
HLA Matching in Pediatric Stem Cell Transplantation.
Transfus Med Hemother 2019;46(5):348-355.

Löhr M, Freitag B, Technau A, Krauss J, Monoranu CM, Rachor J, Lutz MB, Hagemann C, Kessler AF, Linsenmann T, Wölfl M, Ernestus RI, Engelhardt S, Gelbrich G, Schlegel PG, Eyrich M (2018)
High-grade glioma associated immunosuppression does not prevent immune responses induced by therapeutic vaccines in combination with Treg depletion.
Cancer Immunol Immunother. 2018 Oct;67(10):1545-1558.

Seitz CM, Eyrich M, Greil J, Schlegel P, Feuchtinger T, Bader P, Ebinger M, Schwarze CP, Schlegel PG, Schumm M, Handgretinger R, Lang P (2019)
Favorable immune recovery and low rate of GvHD in children transplanted with partially T cell-depleted PBSC grafts. 
Bone Marrow Transplant. 2019 Jan;54(1):53-62.

Sonntag K, Hashimoto H, Eyrich M, Menzel M, Schubach M, Döcker D, Battke F, Courage C, Lambertz H, Handgretinger R, Biskup S, Schilbach K (2018)
Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: a case report. 
J Transl Med. 2018;16(1):23.

Mainardi C, Ebinger M, Enkel S, Feuchtinger T, Teltschik HM, Eyrich M, Schumm M, Rabsteyn A, Schlegel P, Seitz C, Schwarze CP, Müller I, Greil J, Bader P, Schlegel PG, Martin D, Holzer U, Döring M, Handgretinger R, Lang P (2017)
CD34+ selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation.
Br J Haematol. 2017;180(1):90-99.

Eyrich M, Schreiber SC, Rachor J, Krauß J, Pauwels F, Hain J, Wölfl M, Lutz MB, de Vleeschouwer S, Schlegel PG, Van Gool SW (2014)
Development and validation of a fully GMP-compliant production process of autologous, tumor-lysate pulsed dendritic cells.
Cytotherapy. 2014;16(7):946-64.

Eyrich M, Rachor J, Schreiber SC, Wölfl M, Schlegel PG (2014)
Dendritic Cell Vaccination in Pediatric Gliomas: Lessons Learnt and Future Perspectives. Front Pediatr. 2013;10(1):12.

Braun M, Wölfl M, Wiegering V, Winkler B, Ertan K, Bald R, Schwarz K, Heimpel H, Eyrich M, Schlegel PG (2014)
Successful treatment of an infant with CDA type II by intrauterine transfusions and postnatal stem cell transplantation.
Pediatr Blood Cancer. 2014;61(4):743-5.

Wiegering V, Frank J, Freudenberg S, Morbach H, Schlegel PG, Eyrich M, Winkler B (2014) Impaired B-cell reconstitution in children after chemotherapy for standard or medium risk acute precursor B-lymphoblastic leukemia.
Leuk Lymphoma. 2014;55(4):870-5.

Beier R, Albert MH, Bader P, Borkhardt A, Creutzig U, Eyrich M, Ehlert K, Gruhn B, Greil J, Handgretinger R, Holter W, Klingebiel T, Kremens B, Lang P, Mauz-Körholz C, Meisel R, Müller I, Peters C, Reinhardt D, Sedlacek P, Schulz A, Schuster FR, Schrauder A, Strahm B, Sykora KW, Wössmann W, Zimmermann M, Sauer MG (2013)
Allo-SCT using BU, CY and melphalan for children with AML in second CR.
Bone Marrow Transplant. 2013 May;48(5):651-6.

Eyrich M (2013)
Case 19: A one year old boy with SCID.
In: Kröger, N, Aversa F (eds): 34 successful treatment reports. Thieme 2013.

Beier R, Schulz A, Hönig M, Eyrich M, Schlegel PG, Holter W, Stachel KD, Ehlert K, Greil J, Nürnberger W, Wößmann W, Bader P, Urban C, Müller I, Suttorp M, Sauer M, Gruhn B, Meisel R, Zimmermann M, Sykora KW (2013)
Long-term follow-up of children conditioned with Treosulfan: German and Austrian experience.
Bone Marrow Transplant. 2013 Apr;48(4):491-501.

Wiegering V, Winkler B, Haubitz I, Wölfl M, Schlegel PG, Eyrich M (2012)
Lower TGFß serum levels and higher frequency of IFNγ-producing T cells during early immune reconstitution in surviving children after allogeneic stem cell transplantation.
Pediatric Blood&Cancer 2012;60:121-8.

Styczynski J, Balduzzi A, Gil L, Hamladji RM, Marktel S, Yesilipek AM, Fagioli F, Ehlert K, Matulova M, Dalle JH, Wachowiak J, Miano M, Messina C, Diaz MA, Vermylen C, Eyrich M, I Badell I, Dreger P, Gozdzik J, Hutt D, Rascon J, Labopin M, Elarouci N, Dini G, Peters C (2012)
Increased risk of non-severe complications among younger pediatric sibling donors of hematopoietic stem cell collection: a prospective observational study of the EBMT Pediatric Diseases Working Party.
Blood 2012;119:2935-42.

Eyrich M, Schreiber SC, Wollny G, Ziegler H, Schlenker R, Koch-Büttner K, Wölfl M, Schlegel PG, Schilbach K (2011)
Predifferentiated human committed T-lymphoid progenitors promote peripheral T-cell reconstitution after stem cell transplantation in immunodeficient mice.
Eur J Immunol. 2011;41:3596-3603. 

Wiegering V, Eyrich M, Rutkowski S, Wölfl M, Schlegel PG, Winkler B (2011)
TH1 predominance is associated with improved survival in pediatric medulloblastoma patients.
Cancer Immunol Immunother. 2011;60:693-703.

Wölfl M, Merker K, Morbach H, Van Gool SW, Eyrich M, Greenberg PD, Schlegel PG (2011) Primed tumor-reactive multifunctional CD62L(+) human CD8 (+) T cells for immunotherapy.
Cancer Immunol Immunother. 2011;60:173-86.

Thiel U, Wawer A, Wolf P, Badoglio M, Santucci A, Klingebiel T, Basu O, Borkhardt A, Laws HJ, Kodera Y, Yoshimi A, Peters C, Ladenstein R, Pession A, Prete A, Urban EC, Schwinger W, Bordigoni P, Salmon A, Diaz MA, Afanasyev B, Lisukov I, Morozova E, Toren A, Bielorai B, Korsakas J, Fagioli F, Caselli D, Ehninger G, Gruhn B, Dirksen U, Abdel-Rahman F, Aglietta M, Mastrodicasa E, Torrent M, Corradini P, Demeocq F, Dini G, Dreger P, Eyrich M, Gozdzik J, Guilhot F, Holler E, Koscielniak E, Messina C, Nachbaur D, Sabbatini R, Oldani E, Ottinger H, Ozsahin H, Schots R, Siena S, Stein J, Sufliarska S, Unal A, Ussowicz M, Schneider P, Woessmann W, Jürgens H, Bregni M, Burdach S (2011)
No improvement of survival with reduced- versus high-intensity conditioning for allogeneic stem cell transplants in Ewing tumor patients.
Ann Oncol. 2011;22:1614-1621.

Straathof KC, Rao K, Eyrich M, Hale G, Bird P, Berrie E, Brown L, Schlegel PG, Goulden N, Gaspar HB, Gennery AR, Landais P, Davies EG, Brenner MK, Veys PA, Amrolia PJ (2009) Haemopoietic stem cell transplantation with antibody-based minimal intensity conditioning. Lancet 2009;374:912-920.

Schlegel PG, Wolfl M, Schick J, Winkler B, Eyrich M (2009)
Transient loss of consciousness in pediatric recipients of dimethylsulfoxide (DMSO)-cryopreserved peripheral blood stem cells independent of morphine co-medication.
Haematologica 2009;94:1473-1475].

Schilbach K, Frommer K, Meier, S, Handgretinger R, Eyrich M (2008)
Immune response of human propagated γδ-T-cells to neuroblastoma recommend the Vδ1+ subset for γδ-T-cell-based immunotherapy.
J Immunother 2008;31:896-905.

Schilbach K, Schick J, Wehrmann M, Wollny G, Simon P, Schlegel P G, Eyrich M (2007)
PD-1–PD-L1 pathway is involved in suppressing alloreactivity of heart infiltrating T cells during murine GvHD across minor histocompatibility antigen barriers.
Transplantation 2007;84:214-222.

Eyrich M, Winkler B and Schlegel PG (2007)
Stem cell transplantation in Fanconi anemia - recent advances with alternative donors.
In: Schindler D, Hoehn H (eds): Fanconi Anemia. A Paradigmatic Disease for the Understanding of Cancer and Aging.
Monogr Hum Genet. 2007;15:173–182.

Eyrich M, Burger G, Marquardt K, Budach W, Schilbach K, Niethammer D and Schlegel PG (2005)
Sequential expression of adhesion and costimulatory molecules in GvHD target organs after murine bone marrow transplantation across minor histocompatibility antigen barriers. Biology of Blood and Marrow Transplant. 2005; 11:371-382.

Klingebiel T, Lang P, Schumm M, Köhl U, Bader P, Schwabe D, Schlegel PG, Eyrich M, Greil J, Beck JF, Niethammer D, Handgretinger R (2005)
Experiences with haploidentical stem cell transplantation in children with acute lymphoblastic leukemia.
Pathol Biol. 2005;53:159-161.

Eyrich M, Wollny G, Tzaribaschev N, Dietz K, Brügger D, Schilbach K, Winkler B, Bader P, Lang P, Niethammer D, Schlegel PG (2005)
Onset of thymic recovery and plateau of thymic function are differentially regulated after stem cell transplantation in children.
Biology of Blood and Marrow Transplant. 2005; 11:194-205.

Schilbach K, Kerst G, Walter S, Eyrich M, Wernet D, Handgretinger R, Xie W, Rammensee HG, Müller I, Bühring HJ, Niethammer D (2005)
Cytotoxic minor histocompatibility antigen HA 1-specific CD8+ effector memory T cells: Artificial APCs pave the way for clinical application by potent primary in vitro induction. Blood 2005;106:144-149.

Eyrich M, Leiler C, Croner T, Lang P, Schumm M, Mascher B, Schilbach K, Bader P, Klingebiel T, Handgretinger R, Niethammer D, Schlegel PG (2004)
Impaired T-cell activation and cytokine productivity after transplantation of positively selected CD34+ allogeneic hematopoietic stem cells.
The Hematology Journal. 2004; 5:329-340.

Lang P, Klingebiel T, Bader P, Greil J, Schumm M, Schlegel PG, Eyrich M, Mueller-Weihrich S, Niethammer D, Handgretinger R (2004)
Transplantation of highly purified peripheral-blood CD34+ progenitor cells from related and unrelated donors in children with nonmalignant diseases.
Bone Marrow Transplant. 2004;33:25-32.

Eyrich M, Leiler C, Lang P, Schilbach K, Schumm M, Bader P, Greil J, Klingebiel T, Handgretinger R, Niethammer D, Schlegel PG (2003)
A prospective comparison of immune reconstitution in pediatric recipients of positively selected CD34+ peripheral blood stem cells from unrelated donors vs recipients of unmanipulated bone marrow from related donors.
Bone Marrow Transplant. 2003;32:379-390.

Lang P, Handgretinger R, Niethammer D, Schlegel PG, Schumm M, Greil J, Bader P, Engel C, Scheel-Walter H, Eyrich M, Klingebiel T (2003)
Transplantation of highly purified CD34+ progenitor cells from unrelated donors in pediatric leukemia.
Blood. 2003;101:1630-1636.

Eyrich M, Croner T, Leiler C, Lang P, Bader P, Klingebiel T, Niethammer D, Schlegel PG (2002)
Distinct contributions of CD4+ and CD8+ naive and memory T-cell subsets to overall TCR-repertoire complexity following transplantation of T-cell depleted CD34 selected hematopoietic progenitor cells from unrelated donors.
Blood. 2002;100:1915-1918.

Eyrich M, Lang P, Lal S, Bader P, Klingebiel T, Handgretinger R, Niethammer D, Schlegel PG (2001)
A prospective analysis of the pattern of immune reconstitution following transplantation of HLA-disparate hematopoietic stem cells from parental donors.
Br J Haematol. 2001;114:422-432.

Schlegel P, Eyrich M, Bader P, Handgretinger R, Lang P, Niethammer D, Klingebiel T (2000)
OKT-3 based reconditioning regimen for early graft failure in HLA-non-identical stem cell transplants.
Br J Haematol. 2000;111:668-673.