Neuropathic pain induced by anti-Caspr2 autoantibodies: pathogenesis and resolution

Caspr2

In certain types of encephalitis associated with neuropathic pain, autoantibodies against surface proteins of sensory neurons can be detected. One important autoantibody is anti-Caspr2, directed against the surface protein Caspr2. 

Research goal

In project group 3, the pathogenic mechanisms of Caspr2 antibodies on the development of pain will now be investigated in more detail. The project consists of different parts: 

In clinical studies, the prevalence of anti-Caspr2 autoantibodies in painful neuropathies will be investigated and neuropathic pain and its resolution will be further characterized in a cohort of anti-Caspr2-positive patients from the German Network for Research on Autoimmune Encephalitis (GENERATE).

Experimental studies will include animal and cell culture experiments to investigate induction of anti-Caspr2 associated neuropathic pain and its resolution on different levels.

Significance

This project investigates how autoantibodies against Caspr2 induce neuropathic pain and how it can be resolved. Autoantibodies of different subclasses will be investigated.

Research team P3

Head

PD Dr. Kathrin Doppler, MD
Neurological Clinic
University Hospital Würzburg

Univ.-Prof. Dr. rer. nat. Carmen Villmann
Institute for Clinical Neurobiology
University Hospital Würzburg

Members of the team

Patrik Greguletz, PhD Student

Margarita Habib, PhD Student

Luca Buchsteiner, PhD Student

Katharina Fischer, PhD Student

Camille Cauchi, Master Student