Resolution of neuropathies caused by bortezomib and its successor drugs
By integrating clinical, genetic, and biomarker data, the goal is to develop a predictive risk tool for bortezomib-induced peripheral neuropathy (BIPN) and to identify mechanisms that drive pain resolution.
Background
Bortezomib is a widely used treatment for multiple myeloma, but its neurotoxic effects significantly limit its long-term use. BIPN, characterized by sensory disturbances and pain, occurs in up to 30% of patients, with some experiencing persistent symptoms even after treatment cessation. In the first funding period (FP1), the project identified neurofilament light chain (NfL) as a marker of acute axonal damage and discovered genetic and inflammatory markers associated with BIPN severity. The need for targeted prevention and resolution strategies remains critical.
Research Objective
This project will refine and validate a predictive "BIPN Risk Tool" that integrates clinical and genetic markers to identify high-risk patients early. We will further compare the mechanisms of nerve damage caused by BTZ and its successor drugs, including immune mechanisms, genetic and epigenetic factors and pharmacokinetics.
Significance
By identifying biomarkers and genetic predispositions for BIPN, this project aims to enable early intervention and personalized treatment strategies.
Research Team P1
Head
Univ.-Prof. Dr. Martin Kortüm, MD
Chair of Translational Myeloma Research
University Hospital Würzburg
Univ.-Prof. Dr. Hermann Einsele, MD
Professor and Chair of the Department of Internal Medicine II
University Hospital Würzburg
Univ.-Prof. Dr. Claudia Sommer, MD
Speaker of KFO 5001
Department of Neurology and Department of Anesthesiology
University Hospital Würzburg
Members of the team
Dr. rer. nat. Umair Munawar, Researcher
Dr. Xiang Zhou, MD, Clinician Scientist
Nadine Cebulla, PhD Student
Leon Flamm, PhD Student
Nicola Giordani, PhD Student
Johanna Güse, PhD Student
Seungbin Han, PhD Student
Laura-Isabel Jähnel, PhD Student
Calvin Terhorst, PhD Student
Annett Wieser, PhD Student
Felicitas Schoch, PhD Student
Marie-Luise Reinle, PhD Student
